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Titolo:
MEASUREMENT OF MYOCARDIAL BLOOD-FLOW WITH O-15 LABELED WATER - COMPARISON OF DIFFERENT ADMINISTRATION PROTOCOLS
Autore:
HERMANSEN F; ROSEN SD; FATHORDOUBADI F; KOONER JS; CLARK JC; CAMICI PG; LAMMERTSMA AA;
Indirizzi:
AARHUS GEN HOSP,PET CTR,44 NORREBROGADE DK-8000 AARHUS C DENMARK HAMMERSMITH HOSP,IMPERIAL COLL SCH MED,MRC,CYCLOTRON UNIT,PET METHODOL GRP LONDON ENGLAND HAMMERSMITH HOSP,IMPERIAL COLL SCH MED,MRC,CYCLOTRON UNIT,PET CARDIOLGRP LONDON ENGLAND HAMMERSMITH HOSP,IMPERIAL COLL SCH MED,DEPT CARDIOL LONDON ENGLAND
Titolo Testata:
European journal of nuclear medicine
fascicolo: 7, volume: 25, anno: 1998,
pagine: 751 - 759
SICI:
0340-6997(1998)25:7<751:MOMBWO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; QUANTITATIVE MEASUREMENT; TRANSMISSION TOMOGRAPHY; QUANTIFICATION; PERFUSION; (H2O)-O-15; INHALATION; STRATEGY; TRACER; INPUT;
Keywords:
POSITRON EMISSION TOMOGRAPHY; MYOCARDIAL BLOOD FLOW; O-15 LABELED WATER; TRACER KINETIC MODELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
F. Hermansen et al., "MEASUREMENT OF MYOCARDIAL BLOOD-FLOW WITH O-15 LABELED WATER - COMPARISON OF DIFFERENT ADMINISTRATION PROTOCOLS", European journal of nuclear medicine, 25(7), 1998, pp. 751-759

Abstract

Positron emission tomography (PET) in conjunction with (CO2)-O-15 or (H2O)-O-15 can be used to measure myocardial blood flow (MBF) and tissue fraction (TF), i.e, the fraction of the tissue mass in the volume of the region of interest. However, with (CO2)-O-15 inhalation, the tissue fraction in the septum is overestimated. Bolus injection of (H2O)-O-15 together with arterial cannulation gives very precise results butis invasive. The purpose of this study was to develop a method which circumvents these problems. A four-parameter model with parameters forMBF, TF and spill-over fractions from both left and right ventricularcavities was developed. This method was compared with a three-parameter model (no right ventricular cavity spill-over) in both septal and non-septal regions of interest for three different administration protocols: bolus injection of (H2O)-O-15, infusion of (H2O)-O-15 and inhalation of (CO2)-O-15. It was found that MBF can be measured with intravenous administration of (H2O)-O-15 without the requirement for arterialcannulation. The four-parameter protocol with bolus injection was stable in clinical studies. The four-parameter model proved essential forthe septum, where it gave highly significantly better fits than did the three-parameter model (P<0.00003 in each of 15 subjects). Administration of (H2O)-O-15 together with this four-parameter model also circumvented the problem of overestimation of TF in the septum seen with (CO2)-O-15 inhalation. In addition, the radiation dose of (H2O)-O-15 protocols is lower than that of (CO2)-O-15 inhalation. Using a left atrial input curve instead of a left ventricular cavity input curve gave the same mean MBF and TF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:22:33