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Titolo:
THE EFFECTS OF GENDER ON ADRENERGIC-RECEPTOR RESPONSIVENESS
Autore:
LUZIER AB; NAWARSKAS JJ; ANONUEVO J; WILSON MF; KAZIERAD DJ;
Indirizzi:
MILLARD FILLMORE HOSP,CLIN PHARMACOKINET LAB,3 GATES CIRCLE BUFFALO NY 14209 SUNY BUFFALO,SCH PHARM BUFFALO NY 14260 SUNY BUFFALO,SCH MED BUFFALO NY 14260
Titolo Testata:
Journal of clinical pharmacology
fascicolo: 7, volume: 38, anno: 1998,
pagine: 618 - 624
SICI:
0091-2700(1998)38:7<618:TEOGOA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEX-DIFFERENCES; ISOMETRIC-EXERCISE; RESPONSES; STRESS; WOMEN; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
A.B. Luzier et al., "THE EFFECTS OF GENDER ON ADRENERGIC-RECEPTOR RESPONSIVENESS", Journal of clinical pharmacology, 38(7), 1998, pp. 618-624

Abstract

This study was conducted to determine whether gender differences exist in adrenergic receptor sensitivity and baroreflex response. Adrenergic receptor sensitivity was assessed by administering sequentially increasing intravenous doses of phenylephrine and isoproterenol. Baroreflex sensitivity was determined from the slope of pulse intervals plotted against phenylephrine-inducecl rise in systolic blood pressure (SBP). Drug-induced changes in heart rate, blood pressure, and brachial artery diameter were measured and statistically compared. Women required a lower infusion rate of phenylephrine to increase SBP by 20 mmHg frombaseline. There were no statistically significant gender-related differences in baroreflex sensitivity. The dose of isoproterenol needed toincrease heart rate by 25 beats per minute from baseline also did notdiffer significantly between groups. Percent changes from baseline inbrachial artery diameters in response to phenylephrine also were similar between groups. These data suggest that women may have greater alpha-adrenergic receptor sensitivity than men, whereas beta(1)-adrenergic receptor sensitivity is similar between genders. A trend toward a greater baroreflex sensitivity in men than in women was also observed. This study also provides evidence for a possible relationship between adrenergic receptor sensitivity and baroreflex sensitivity. Journal of Clinical Pharmacology, 1998;38:618-624 (C)1998 The American College ofClinical Pharmacology.

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Documento generato il 23/10/20 alle ore 10:08:24