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Titolo:
AMBISOME (LIPOSOMAL AMPHOTERICIN-B) - A COMPARATIVE REVIEW
Autore:
BOSWELL GW; BUELL D; BEKERSKY I;
Indirizzi:
FUJISAWA USA INC,EXPT THERAPEUT,3 PKWY N DEERFIELD IL 60015 FUJISAWA USA INC,EXPT THERAPEUT DEERFIELD IL 60015
Titolo Testata:
Journal of clinical pharmacology
fascicolo: 7, volume: 38, anno: 1998,
pagine: 583 - 592
SICI:
0091-2700(1998)38:7<583:A(A-AC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID COMPLEX; PHARMACOKINETICS; FORMULATION; TOXICITY; TISSUE; SAFETY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
G.W. Boswell et al., "AMBISOME (LIPOSOMAL AMPHOTERICIN-B) - A COMPARATIVE REVIEW", Journal of clinical pharmacology, 38(7), 1998, pp. 583-592

Abstract

AmBisome (NeXstar Pharmaceuticals, San Dimas, CA) is a unilamellar liposomal formulation of amphotericin B that was recently approved for use as empirical treatment for presumed fungal infections in febrile neutropenic patients and for aspergillosis, candidiasis, and cryptococcosis infections refractory to amphotericin B. It is a small closed microscopic sphere (<100 nm in diameter) with an inner aqueous core (i.e.,a true liposome). AmBisome remains at an intact sphere in vitro and for prolonged periods of time in vivo during the processes of systemic transport and pharmacologic action. As a consequence of its size and in vivo stability, AmBisome has physiochemical properties and a pharmacokinetic profile that ar e considerably different from those of currently available lipid-complexed amphotericin B formulations, with greatly increased area under the plasma concentration-time curve and much lower clearance at equivalent doses. AmBisome liposomes can be seen to accumulate at sites of fungal infection. Disruption of AmBisome liposomes occurs after attachment to the fungal cell wall and results in amphotericin B binding to fungal cell membrane ergosterol with subsequent cell lysis. AmBisome has been shown to penetrate the cell wall of bathextracellular and intracellular forms of susceptible fungi. Journal of Clinical Pharmacology, 1998;38:583-592 (C)1998 The American College of Clinical Pharmacology.

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Documento generato il 11/08/20 alle ore 14:53:24