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Titolo:
INCREASED NIGHT-DAY BLOOD-PRESSURE RATIO IN MICROALBUMINURIC NORMOTENSIVE NIDDM SUBJECTS
Autore:
INABA M; NEGISHI K; TAKAHASHI M; SERIZAWA N; MARUNO Y; TAKAHASHI K; KATAYAMA S;
Indirizzi:
SAITAMA MED SCH,DEPT MED 4,38 MOROHONGO MOROYAMA SAITAMA 35004 JAPAN SAITAMA MED SCH,DEPT MED 4 MOROYAMA SAITAMA 35004 JAPAN
Titolo Testata:
Diabetes research and clinical practice
fascicolo: 3, volume: 40, anno: 1998,
pagine: 161 - 166
SICI:
0168-8227(1998)40:3<161:INBRIM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; AUTONOMIC NEUROPATHY; NON-DIPPERS; HYPERTENSION; NEPHROPATHY; PROFILE; SLEEP;
Keywords:
TYPE 2 DIABETES MELLITUS; NORMOTENSION; MICROALBUMINURIA; BLOOD PRESSURE MONITORING; DIPPER; NON-DIPPER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Inaba et al., "INCREASED NIGHT-DAY BLOOD-PRESSURE RATIO IN MICROALBUMINURIC NORMOTENSIVE NIDDM SUBJECTS", Diabetes research and clinical practice, 40(3), 1998, pp. 161-166

Abstract

Objective: To determine the relationship of day- and night-time bloodpressure (BP) with the degree of albuminuria in subjects with non-insulin-dependent diabetes (NIDDM). Research design and methods: BP was determined hourly for 24 h in 27 NIDDM normotensive patients, and 10 age- and BMI-matched controls. Diabetic subjects were separated into normo- and microalbuminuric groups according to the urinary albumin excretion rate (AER < 15 and greater than or equal to 15 mu g/min), respectively. Results: Non-dippers defined by a nocturnal fall in BP of less then 10/5 mmHg represented 68.8% of the normo- and 81.8% of the microalbuminuric patients. Microalbuminuric diabetics demonstrated a significantly higher ratio of night:day BP in comparison to controls, but notto normoalbuminuric diabetics. AER was significantly correlated with BP ratio in the normoalbuminuric, but not in microalbuminuric group. Conclusions: Ambulatory 24-h BP monitoring is useful to find blunted nocturnal fall in BP even in normotensive NIDDM subjects with or withoutmicroalbuminuria. However, whether or not an increase in the night-time BP and/or the night:day ratio in NIDDM patients plays a pathogenetic role in the progression of diabetic nephropathy remains to be clarified. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 28/11/20 alle ore 21:18:56