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Titolo:
A 2ND MAJOR NATIVE VON-HIPPEL-LINDAU GENE-PRODUCT, INITIATED FROM AN INTERNAL TRANSLATION START SITE, FUNCTIONS AS A TUMOR-SUPPRESSOR
Autore:
SCHOENFELD A; DAVIDOWITZ EJ; BURK RD;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,CTR CANC RES,DEPT MICROBIOL & IMMUNOL,1300 MORRIS PK AVE BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,CTR CANC RES,DEPT MICROBIOL & IMMUNOL BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,CTR CANC RES,DEPT PEDIAT BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,CTR CANC RES,DEPT EPIDEMIOL & SOCIAL MED BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,MARION BESSIN LIVER RES CTR BRONX NY 10461
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 15, volume: 95, anno: 1998,
pagine: 8817 - 8822
SICI:
0027-8424(1998)95:15<8817:A2MNVG>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; RENAL-CELL CARCINOMA; FACTOR MESSENGER-RNA; DISEASE; PROTEIN; MUTATIONS; IDENTIFICATION; BINDING; LOCALIZATION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
A. Schoenfeld et al., "A 2ND MAJOR NATIVE VON-HIPPEL-LINDAU GENE-PRODUCT, INITIATED FROM AN INTERNAL TRANSLATION START SITE, FUNCTIONS AS A TUMOR-SUPPRESSOR", Proceedings of the National Academy of Sciences of the United Statesof America, 95(15), 1998, pp. 8817-8822

Abstract

The von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in both sporadic and inherited clear cell renal carcinoma associated with VHL disease. We have identified tyro distinct native products of the human VHL gene, with apparent molecular masses of 24 and 18 kDa. The 18-kDa VHL protein was more abundant in nearly all cell lines examined. Reintroduction of the 18-kDa VHL gene product into renal carcinoma cells lacking wild-type VHL protein led to down-regulation of vascular endothelial growth factor (VEGF) mRNA and glucose transporter GLUT1 protein and suppressed tumor formation in nude mice. The 18-kDa VHL protein also demonstrated binding to elongins B and C. In an in vitro assay,the second in-frame AUG codon present in VHL mRNA was shown to be necessary and sufficient for production of the 18-kDa VHL protein, consistent with an internal translation mechanism. These data provide evidence for a second major VHL gene product, which contains the functional domains of the VHL gene. Moreover, these results indicate that internal translation initiation is an important mechanism for production of the major VHL protein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 08:04:13