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Titolo:
ALLOGENEIC PERIPHERAL-BLOOD PROGENITOR-CELL TRANSPLANTATION CONDITIONED WITH ANTI-THYMOCYTE GLOBULIN FOR TREATMENT OF GRAFT FAILURE AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION
Autore:
TANABE J; MARUTA A; KOHARAZAWA H; HATTORI M; KODAMA F; OKUBO T;
Indirizzi:
KANAGAWA CANC CTR,DEPT HEMATOL & CHEMOTHERAPY,ASAHI KU,1-1-2 NAKAO YOKOHAMA KANAGAWA JAPAN
Titolo Testata:
International journal of hematology
fascicolo: 4, volume: 67, anno: 1998,
pagine: 423 - 427
SICI:
0925-5710(1998)67:4<423:APPTC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; SEVERE APLASTIC-ANEMIA; MYELOID-LEUKEMIA; 2ND TRANSPLANT; CYCLOPHOSPHAMIDE; ENGRAFTMENT; REJECTION; INFUSION; BUSULFAN; RISK;
Keywords:
ANTI-THYMOCYTE GLOBULIN (ATG); LATE GRAFT FAILURE; PERIPHERAL BLOOD PROGENITOR CELLS (PBPC);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
J. Tanabe et al., "ALLOGENEIC PERIPHERAL-BLOOD PROGENITOR-CELL TRANSPLANTATION CONDITIONED WITH ANTI-THYMOCYTE GLOBULIN FOR TREATMENT OF GRAFT FAILURE AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION", International journal of hematology, 67(4), 1998, pp. 423-427

Abstract

A 43-year-old female with AML-M1 developed late graft failure 4 months after her first allogeneic bone marrow transplant. The patient then underwent a second transplant with peripheral blood progenitor cells obtained from the same HLA-identical brother. The donor peripheral blood progenitor cells were mobilized with granulocyte colony-stimulating factor (10 mu g/kg daily s.c. for 6 days). The patient received horse anti-thymocyte globulin alone (15 mg/kg per day for 5 days) as the conditioning regimen. Rapid hematopoietic recovery followed a sustained engraftment. The time to reach 0.5 x 10(9)/l neutrophils and 25 x 10(9)/l platelets was 10 and 12 days, respectively. Cytogenetic analysis ofbone marrow performed on day +20 demonstrated a 46XY karyotype of donor origin. There was no acute graft-versus-host disease. The patient remains in complete remission with a Karnofsky score of 90% 5 months after peripheral blood progenitor cell transplantation. To treat graft failure after allogeneic bone marrow transplantation, allogeneic peripheral blood progenitor cell transplantation conditioned with anti-thymocyte globulin alone should be considered as a feasible alternative to marrow transplant. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 05/04/20 alle ore 06:54:44