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Titolo:
THE BEHAVIORAL-EFFECTS OF CORTICOTROPIN-RELEASING FACTOR-RELATED PEPTIDES IN RATS
Autore:
JONES DNC; KORTEKAAS R; SLADE PD; MIDDLEMISS DN; HAGAN JJ;
Indirizzi:
SMITHKLINE BEECHAM PHARMACEUT PLC,NEUROSCI RES,NEW FRONTIERS SCI PK,3RD AVE HARLOW CM19 5AW ESSEX ENGLAND
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 138, anno: 1998,
pagine: 124 - 132
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE REFLEX; UROTENSIN-I; BINDING-PROTEIN; FACTOR CRF; UROCORTIN; RECEPTOR; NEUROPEPTIDE; SAUVAGINE; STRESS; HEART;
Keywords:
SAUVAGINE; UROTENSIN I; CORTICOTROPIN-RELEASING FACTOR; UROCORTIN; HYPOPHAGIA; ANXIOGENESIS; HYPERACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
D.N.C. Jones et al., "THE BEHAVIORAL-EFFECTS OF CORTICOTROPIN-RELEASING FACTOR-RELATED PEPTIDES IN RATS", Psychopharmacology, 138(2), 1998, pp. 124-132

Abstract

The present study determined the behavioural effects of the corticotropin releasing factor (CRF)-related peptides, human/rat CRF (h/rCRF), ovine CRF (oCRF), sauvagine (SAUV), urotensin I(UT) and the recently discovered neuropeptide, rat urocortin (rUCN). All of the peptides dose-dependently increased motor activity in a familiar environment and reduced feeding in hungry rats. There was no apparent relationship between potency/affinity at CRF2 receptors and effects in these two tests. In a comparison of h/rCRF and rUCN upon discrete spontaneous behaviours, both peptides (3.0 mu g ICV) increased activity and grooming, induced a fore-paw tremor and reduced the incidence of motionlessness. However, h/rCRF reduced motionlessness to a greater extent and was a more potent inducer of defaecation, weight loss, oral movements and fore-paw tremor than rUCN. In the elevated X maze, both h/rCRF and rUCN (1.0 mu g ICV) had anxiogenic-like effects upon behaviour. In contrast, h/rCRF (1.0 mu g ICV), but not rUCN (1.0-10 mu g ICV) increased the startle response to an acoustic stimulus. In summary, all the CRF-related peptides increased motor activity and reduced feeding in rats in a similar manner and both rUCN and h/rCRF induced anxio-genesis. However, there were some behavioural differences between rUCN and h/rCRF which require further study. Further pharmacological investigation of the roleof CRF receptor subtypes requires the use of subtype selective antagonists.

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Documento generato il 20/01/20 alle ore 05:07:46