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Titolo:
THE USE OF HUMAN GLUTATHIONE-S-TRANSFERASE A(1) IN THE DETECTION OF CYSTIC-FIBROSIS LIVER-DISEASE
Autore:
HUNG JCC; HOWIE AF; BECKETT GJ; SOOD M; HAMBLETON G; SUPER M;
Indirizzi:
ROYAL LIVERPOOL CHILDRENS HOSP,ALDER HEY,EATON RD LIVERPOOL L12 2AP MERSEYSIDE ENGLAND ROYAL MANCHESTER CHILDRENS HOSP MANCHESTER M27 1HA LANCS ENGLAND ROYAL INFIRM,DEPT CLIN BIOCHEM EDINBURGH MIDLOTHIAN SCOTLAND
Titolo Testata:
Journal of paediatrics and child health
fascicolo: 4, volume: 34, anno: 1998,
pagine: 335 - 338
SICI:
1034-4810(1998)34:4<335:TUOHGA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
URSODEOXYCHOLIC ACID THERAPY; HEPATOCELLULAR DAMAGE; PLASMA; SONOGRAPHY; PANCREAS; SYSTEM;
Keywords:
CYSTIC FIBROSIS; GLUTATHIONE S-TRANSFERASE; LIVER DISEASE; LIVER FUNCTION TESTS; ULTRASONOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
J.C.C. Hung et al., "THE USE OF HUMAN GLUTATHIONE-S-TRANSFERASE A(1) IN THE DETECTION OF CYSTIC-FIBROSIS LIVER-DISEASE", Journal of paediatrics and child health, 34(4), 1998, pp. 335-338

Abstract

Objective: To determine the value of serum human glutathione S-transferase A(1) (hGST A(1)) in the detection of cystic fibrosis liver disease (CFLD). Methods: Sixty-three children (aged 0.5-16 years) with cystic fibrosis (CF) were screened prospectively for evidence of hepatobiliary abnormalities between February 1993 and February 1995. Comparisonwas made between clinical examination, abdominal ultrasonic scan, measurement of conventional liver enzymes (LFTs) and serum hGST A(1) concentration in the detection of hepatobiliary abnormalities in children with CF, Results: The 5-95% concentration of serum hGST A(1) was 1.7-4.27 mu g L-1 for the control group. The hGST A(1) levels in the CF patients were significantly higher than in the non-CF group. Thirty-eight(60%) children had detectable hepatobiliary abnormalities. Ultrasoundscanning detected the highest number of abnormalities (41%), followedby hGST A(1) (30%). The presence of clinical liver disease was found in 19% of the children. The estimated sensitivities of detecting CFLD by clinical method, ultrasound scan, serum hGST A(1), and LFTs would be 32%, 68%, 50% and 16%, respectively. Conclusions: Serum hGST A(1) measurement increases the sensitivity of detecting hepatic abnormalitieswhen included with clinical and ultrasound evaluation although, in some cases with advanced liver disease, serum hGST A(1) may be normal. Conventional liver enzyme tests add little information in the detectionof CF liver disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:52:35