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Titolo:
MAPPING OF TYROSINE KINASE GENE FAMILY MEMBERS IN A XIPHOPHORUS MELANOMA MODEL
Autore:
MORIZOT DC; MCENTIRE BB; DELLACOLETTA L; KAZIANIS S; SCHARTL M; NAIRN RS;
Indirizzi:
UNIV TEXAS,MD ANDERSON CANC CTR,DIV SCI PK RES,POB 389 SMITHVILLE TX 78957 UNIV WURZBURG,BIOZENTRUM,THEODOR BOVERI INST BIOWISSENSCH D-97074 WURZBURG GERMANY
Titolo Testata:
Molecular carcinogenesis
fascicolo: 3, volume: 22, anno: 1998,
pagine: 150 - 157
SICI:
0899-1987(1998)22:3<150:MOTKGF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT-MELANOMA; C-YES; LINKAGE; POECILIIDAE; FISH; EXPRESSION; ASSIGNMENT; PLATYFISH; TELEOSTEI; PROTEIN;
Keywords:
FYN AND YES ONCOGENES; PLATYFISH-SWORDTAIL HYBRID MELANOMA; GENE MAPPING; TYROSINE KINASE GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
D.C. Morizot et al., "MAPPING OF TYROSINE KINASE GENE FAMILY MEMBERS IN A XIPHOPHORUS MELANOMA MODEL", Molecular carcinogenesis, 22(3), 1998, pp. 150-157

Abstract

Xiphophorus fish have been the subject of intensive genetic research for more than 60 yr, primarily because of the availability of a numberof interspecific hybrids that are malignant melanoma models with apparently simple oncogene and tumor suppressor gene determinants. The gene map of Xiphophorus is one of the most extensive among nonhuman vertebrates, with about 100 genes assigned to at least 20 independently asserting linkage groups (LGs), as well as more than 250 anonymous DNA sequence markers, providing coverage for most of the genome for genetic mapping studies. This characteristic has resulted in the mapping of a tumor suppressor locus, DIFF; which is one of two genetic determinantsof melanoma formation in the best-studied hybrid melanoma, the Gordon-Kosswig melanoma model. The other gene responsible for melanoma formation in this model is a sex-linked tyrosine kinase gene related to EGFR and called Xiphophorus melanoma receptor kinase (Xmrk). The cellularoncogene homologues of the non-receptor tyrosine kinase family orthologous to yes and fyn have also been found to be overexpressed in malignant melanomas of Xiphophorus and may be involved in tumor progression. We report here the map location of a Xiphophorus yes gene, YES?, in LG VI, closest to the EGFR gene and the assignment of a fyn gene homologue to newly designated LG XV, linked to the gene for cytosolic alpha-galactosidase. We also confirmed that an EGFR-related sequence (EGFRL1) that we previously assigned to Xiphophorus LG VI by cross-hybridization to a viral erbB probe was the EGFR orthologue. Our results suggest that the presence of expressed duplicates of members of the tyrosine kinase gene family in teleost fishes may increase the potential number of targets in oncogenic cascades in fish tumor models. Mel. Carcinog. 22.150-157, 1998. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 15:50:18