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Titolo:
KINETICS OF EXPRESSION OF COSTIMULATORY MOLECULES AND THEIR LIGANDS IN MURINE RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN-VIVO
Autore:
ISSAZADEH S; NAVIKAS V; SCHAUB M; SAYEGH M; KHOURY S;
Indirizzi:
CTR NEUROL DIS,77 AVE LOUIS PASTEUR BOSTON MA 02115 CTR NEUROL DIS BOSTON MA 02115 HARVARD UNIV,SCH MED,BRIGHAM & WOMENS HOSP,LAB IMMUNOGENET & TRANSPLANTAT BOSTON MA 02115
Titolo Testata:
The Journal of immunology (1950)
fascicolo: 3, volume: 161, anno: 1998,
pagine: 1104 - 1112
SICI:
0022-1767(1998)161:3<1104:KOEOCM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; MYELIN BASIC-PROTEIN; T-CELL ACTIVATION; MESSENGER-RNA EXPRESSION; GROWTH-FACTOR-BETA; ANTIGEN-PRESENTING CELLS; CD40 LIGAND; CYTOKINE PRODUCTION; DENDRITIC CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
S. Issazadeh et al., "KINETICS OF EXPRESSION OF COSTIMULATORY MOLECULES AND THEIR LIGANDS IN MURINE RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN-VIVO", The Journal of immunology (1950), 161(3), 1998, pp. 1104-1112

Abstract

We studied the kinetics of expression of costimulatory molecules and cytokines in the central nervous system (CNS) in murine relapsing experimental autoimmune encephalomyelitis (EAE). During the natural courseof EAE, B7-2 expression in the CNS correlated with clinical signs, while B7-1 was exclusively expressed during remissions. Interestingly, B7-1 was expressed on infiltrating mononuclear cells as well as neuronal cells in the CNS, Zn the periphery, B7-1 expression on APCs peaked with clinical disease but decreased on T cells. CD28 and CTLA4 molecules, the two known ligands for B7-1 and B7-2, had distinct expression patterns in the CNS; CD28 was highly expressed and correlated with B7-2 expression on APCs (macrophages/microglia as web as astrocytes) and with the clinical signs of EAE. CTLA4, on the other hand, was expressed by substantially fewer cells during the effector phase of disease and peaked during remission, which is consistent with the emerging role ofthis molecule in the termination of immune responses. The expression of CD40 and CD40L in the CNS was increased during clinical attacks. The expression of IL-12, IFN-gamma, and TNF-alpha correlated with disease activity and severity, while TGF-beta was the only factor that was up-regulated during the recovery phase. interestingly, TGF-beta was also expressed by neurons during remission. This is the first study demonstrating the kinetics of the in vivo expression of costimulatory molecules, their ligands, and cytokines in an autoimmune disease model characterized by remissions and relapses. Our data suggest that the targeting of costimulatory molecules to block an immune response must take into account the expression patterns in the target organ.

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Documento generato il 27/09/20 alle ore 22:44:47