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Titolo:
PREVALENCE AND COURSE OF HEPATITIS-C INFECTION IN PREGNANCY
Autore:
HILLEMANNS P; LANGENEGGER P; LANGER BCA; KNITZA R; HASBARGEN U; HEPP H;
Indirizzi:
KLINIKUM GROSSHADERN,FRAUENKLIN,KLIN & POLIKLIN FRAUENHEILKUNDE & GEBURTSHILFE,MARCHIONINISTR 15 D-81377 MUNICH GERMANY UNIV MUNICH,MAX VON PETTENKOFER INST MUNICH GERMANY
Titolo Testata:
Zeitschrift fur Geburtshilfe und Perinatologie
fascicolo: 3, volume: 202, anno: 1998,
pagine: 127 - 130
SICI:
0948-2393(1998)202:3<127:PACOHI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
GER
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; TO-INFANT TRANSMISSION; VERTICAL TRANSMISSION; MOTHERS; GENOME;
Keywords:
HEPATITIS C VIRUS; SCREENING; PREGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
P. Hillemanns et al., "PREVALENCE AND COURSE OF HEPATITIS-C INFECTION IN PREGNANCY", Zeitschrift fur Geburtshilfe und Perinatologie, 202(3), 1998, pp. 127-130

Abstract

Hepatitis C shows an increasing distribution in countries of western Europe. The aim of our study was to assess the prevalence of antibodies to hepatitis C (anti-HCV) in pregnancy, to evaluate the risk factorsfor anti-HCV positive women and the course of hepatitis C during pregnancy. 3712 pregnant patients of the university hospital Grosshadern, Munich, were analyzed for anti-HCV, anti-HIV and hepatitis B surface antigen. Anti-HCV seropositive women were further tested with western blot and polymerase chain reaction for HCV-RNA. Thirty-five (0.94%) of the 3712 pregnant women were found anti-HCV positive. 20% of them had present or previous injection drug abuse, hereof one patient had an associated seropositivity for HIV. Parenteral transmission through bloodtransfusion was likely in 11%. However, no parenteral exposure was recognized in 57% of the anti-HCV positive patients. The presence of serum HCV-RNA was detected in 16 (57%) of the 28 patients tested. In 17% (6/35) of the anti-HCV positive pregnancies elevated liver enzymes were noted, which did not show any significant change during the course of pregnancy. In conclusion, the prevalence of hepatitis C in pregnancyis relatively high with nearly 1%-comparable to chronic hepatitis B infection. Selected pregnancy screening based on perceived high-risk groups alone fail to detect about 60% of HCV antibody-positive women. Pregnancy did not influence the course of hepatitis C.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:44:06