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Titolo:
GENISTEIN SUPPRESSES ADHESION-INDUCED PROTEIN-TYROSINE PHOSPHORYLATION AND INVASION OF B16-BL6 MELANOMA-CELLS
Autore:
YAN CH; HAN R;
Indirizzi:
CHINESE ACAD MED SCI,INST MAT MED,DEPT PHARMACOL 1,1 XIAN NONG TAN STBEIJING 100050 PEOPLES R CHINA CHINESE ACAD MED SCI,INST MAT MED,DEPT PHARMACOL 1 BEIJING 100050 PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050 PEOPLES R CHINA
Titolo Testata:
Cancer letters
fascicolo: 1, volume: 129, anno: 1998,
pagine: 117 - 124
SICI:
0304-3835(1998)129:1<117:GSAPP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR-MATRIX; SIGNAL-TRANSDUCTION; INVITRO ASSAY; TUMOR-CELLS; KINASE; EXPRESSION; CANCER; FIBRONECTIN; COLLAGENASE; INHIBITION;
Keywords:
PROTEIN TYROSINE PHOSPHORYLATION; CELL-EXTRACELLULAR MATRIX INTERACTION; INVASION; GENISTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
C.H. Yan e R. Han, "GENISTEIN SUPPRESSES ADHESION-INDUCED PROTEIN-TYROSINE PHOSPHORYLATION AND INVASION OF B16-BL6 MELANOMA-CELLS", Cancer letters, 129(1), 1998, pp. 117-124

Abstract

Protein tyrosine phosphorylation occurs as one of the earlier events in cancer cell-extracellular matrix (ECM) interaction. With immunoblotanalysis and immunofluorescence microscopy, genistein was found to suppress the tyrosine phosphorylation of proteins located at the cell periphery, including a 125 kDa protein, when B16-BL6 melanoma cells attached to and interacted with ECM. When accompanied by the suppression of adhesion-induced protein tyrosine phosphorylation, the invasive potential of B16-BL6 cells through reconstituted basement membrane was decreased significantly. However, neither adhesive capability nor cell growth was significantly affected by genistein. Therefore, the interruption of cancer cell-ECM interaction by suppression of protein tyrosine phosphorylation may contribute to invasion prevention of genistein. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:08:56