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Titolo:
OPPOSITE EFFECTS OF CCKB AGONISTS IN GROOMING BEHAVIOR IN RATS - FURTHER EVIDENCE FOR 2 CCKB SUBSITES
Autore:
LADURELLE N; SEBRET A; GARBAY C; ROQUES BP; DAUGE V;
Indirizzi:
FAC SCI PHARMACEUT & BIOL PARIS,CNRS,URA D1500,INSERM,U266,DEPT PHARMACOCHIM MOL & STRUCT F-75270 PARIS 06 FRANCE FAC SCI PHARMACEUT & BIOL PARIS,CNRS,URA D1500,INSERM,U266,DEPT PHARMACOCHIM MOL & STRUCT F-75270 PARIS 06 FRANCE
Titolo Testata:
British Journal of Pharmacology
fascicolo: 6, volume: 124, anno: 1998,
pagine: 1091 - 1098
SICI:
0007-1188(1998)124:6<1091:OEOCAI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ RECEPTOR; B RECEPTOR; BINDING-SITES; PLUS-MAZE; BRAIN; ANTAGONISTS; ANXIETY; L-365,260; DOPAMINE; STATES;
Keywords:
CCKB RECEPTOR SUBSITES, BC197; BC264; GROOMING ACTIVITY; DOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
N. Ladurelle et al., "OPPOSITE EFFECTS OF CCKB AGONISTS IN GROOMING BEHAVIOR IN RATS - FURTHER EVIDENCE FOR 2 CCKB SUBSITES", British Journal of Pharmacology, 124(6), 1998, pp. 1091-1098

Abstract

1 The hypothesis of the existence of two CCKB receptor subsites, CCKB1 and CCKB2 corresponding probably to different coupling states of CCKB receptors, was studied by measuring grooming behaviour in rats. 2 The B1 receptor agonist, BC197 (300 mu g kg(-1), i.p.) produced a 45-50%decrease in grooming activity, which was prevented by both the CCKB receptor antagonists CI-988 (20 mu g kg(-1) i.p.) and L-365,260 (200 mug kg(-1), i.p.). 3 In contrast, 3, 10 and 30 mu g kg(-1), i.p., of the potent B2 receptor agonist, BC264, enhanced grooming (150-190%). This effect was prevented by previous injection of 75 mu g kg(-1) of L-365,260 while higher doses (200 mu g kg(-1), i.p.) produced only a partial antagonism. Moreover, CI-988 (20 mu g kg(-1), i.p.), showed an opposite effect in potentiating the responses induced by BC264. However, 200 mu g kg(-1) of CI-988 tended to suppress the increase of grooming induced by BC264. 4 The effects of BC264 were prevented by the D-1 receptor (SCH 23390) and D-2 receptor (sulpiride) antagonists, while thoseof BC197 were only antagonized by sulpiride, emphasizing the existence of a link between peptidergic (CCK) and dopaminergic systems. 5 Thisstudy brings additional evidence for the existence of the two CCKB receptor subsites and suggests that particular attention should be focused on the selectivity of CCKB receptor agonists, notably to explain the fact that some compounds such as Boc-CCK4 induce anxiogenic-like effects while others, including BC264, are devoid of these effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:59:10