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Titolo:
INFECTION OF WHV C-MYC TRANSGENIC MICE WITH MOLONEY MURINE LEUKEMIA-VIRUS AND PROVIRAL INSERTION NEAR THE SYNDECAN-4 GENE IN AN EARLY LIVER-TUMOR/
Autore:
RENARD CA; TRANSY C; TIOLLAIS P; BUENDIA MA;
Indirizzi:
INST PASTEUR,INSERM,U163,UNITE RECOMBINAISON & EXPRESS GENET F-75724 PARIS 15 FRANCE INST PASTEUR,INSERM,U163,UNITE RECOMBINAISON & EXPRESS GENET F-75724 PARIS 15 FRANCE
Titolo Testata:
Research in virology (Paris)
fascicolo: 3, volume: 149, anno: 1998,
pagine: 133 - 143
SICI:
0923-2516(1998)149:3<133:IOWCTM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ECOTROPIC RETROVIRUS RECEPTOR; GROWTH-FACTOR; CELL-SURFACE; C-MYC; EXPRESSION; ACTIVATION; PROMOTER; ORGANIZATION; HEPATOCYTES; PROTEIN;
Keywords:
RETROVIRUS; CARCINOGENESIS; MOMLV; INSERTIONAL MUTAGENESIS; C-MYC; HEPATOCELLULAR CARCINOMA; HEPATITIS B VIRUS; SYNDECAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Renard et al., "INFECTION OF WHV C-MYC TRANSGENIC MICE WITH MOLONEY MURINE LEUKEMIA-VIRUS AND PROVIRAL INSERTION NEAR THE SYNDECAN-4 GENE IN AN EARLY LIVER-TUMOR/", Research in virology (Paris), 149(3), 1998, pp. 133-143

Abstract

The capacity of Moloney murine leukaemia virus (MoMLV) to infect neonatal hepatocytes and to accelerate liver carcinogenesis was examined in a transgenic mouse model. WHV/c-myc mice which are highly susceptible to the development of liver tumours were infected with MoMLV shortlyafter birth, when expression of the murine ecotropic retroviral receptor gene was still detectable in the neonatal liver. All MoMLV-infected transgenic mice and non-transgenic littermates succumbed to T-cell lymphomas within 2-9 months; during this period of time, three infectedtransgenic animals developed primary hepatocellular carcinomas. Remarkably, one of these liver tumours arose significantly faster than tumours from uninfected WHV/c-myc controls, and it harboured a unique MoMLV provirus. The provirus integration site was located 5.5 kb upstream of the first exon of the syndecan-4 gene, which encodes a heparan sulphate proteoglycan implicated in growth factor activation and protein kinase C distribution in focal adhesions. Our data provide evidence forclonal MoMLV provirus integration in a hepatocellular carcinoma, and indicate that parenchymal liver cells may be susceptible to MoMLV infection following neonatal inoculation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 03:06:08