Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF WAY-100135 ON THE HIPPOCAMPAL ACETYLCHOLINE-RELEASE POTENTIATED BY 8-OH-DPAT, A SEROTONIN(1A) RECEPTOR AGONIST, IN NORMAL AND P-CHLOROPHENYLALANINE-TREATED RATS AS MEASURED BY IN-VIVO MICRODIALYSIS
Autore:
NAKAI K; FUJII T; FUJIMOTO K; SUZUKI T; KAWASHIMA K;
Indirizzi:
KYORITSU COLL PHARMACEUT SCI,DEPT PHARMACOL,MINATO KU,1-5-30 SHIBAKOEN TOKYO 1058512 JAPAN KYORITSU COLL PHARMACEUT SCI,DEPT PHARMACOL,MINATO KU TOKYO 1058512 JAPAN
Titolo Testata:
Neuroscience research
fascicolo: 1, volume: 31, anno: 1998,
pagine: 23 - 29
SICI:
0168-0102(1998)31:1<23:EOWOTH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTSYNAPTIC 5-HT(1A) RECEPTORS; FREELY MOVING RATS; IN-VIVO; 5-HT1A AGONISTS; EXTRACELLULAR ACETYLCHOLINE; SELECTIVE ANTAGONIST; BRAIN MICRODIALYSIS; DORSAL HIPPOCAMPUS; CEREBRAL-CORTEX; CONSCIOUS RATS;
Keywords:
ACETYLCHOLINE; HIPPOCAMPUS; 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; MICRODIALYSIS; RADIOIMMUNOASSAY; SEROTONIN(1A) RECEPTOR; (+)WAY-100135;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
K. Nakai et al., "EFFECT OF WAY-100135 ON THE HIPPOCAMPAL ACETYLCHOLINE-RELEASE POTENTIATED BY 8-OH-DPAT, A SEROTONIN(1A) RECEPTOR AGONIST, IN NORMAL AND P-CHLOROPHENYLALANINE-TREATED RATS AS MEASURED BY IN-VIVO MICRODIALYSIS", Neuroscience research, 31(1), 1998, pp. 23-29

Abstract

The mechanisms involved in the enhancement of acetylcholine (ACh) release in the rat hippocampus by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a serotonin (5-HT)(1A) receptor agonist, were investigated using in vivo microdialysis. Administration of p-chlorophenylalanine(PCPA, 300 mg/kg, i.p.), a tryptophan hydroxylase inhibitor, 3 days before the dialysis experiments reduced the hippocampal 5-HT content to30% of that in saline-treated rats, but did not affect basal ACh release in the hippocampus. 8-OH-DPAT administered systemically (0.5 mg/kg, s.c.) or applied locally (30 mu M) into the hippocampus through the dialysis probe significantly enhanced the release of ACh in the hippocampus of PCPA-treated rats to the same degree as that in saline-treated rats. Pretreatment with (+)WAY-100135 (5 mg/kg, i.p.), a selective 5-HT1A receptor antagonist, completely eliminated the enhancement of ACh release induced by locally applied 8-OH-DPAT, but only partially reduced the effects induced by systemically administered 8-OH-DPAT, in both groups of rats. Systemically administered 8-OH-DPAT induced hyperlocomotion in the both saline- and PCPA-treated rats, but this was not eliminated by(+)WAY-100135. 8-OH-DPAT applied locally into the hippocampus did not elicit hyperlocomotion in either group of rats. These results suggest that the modification of endogenous 5-HT release via the 5-HT1A autoreceptor is not involved in the 8-OH-DPAT-induced increase of hippocampal ACh release, and that the increase of ACh release induced by locally applied 8-OH-DPAT involves mainly hippocampal postsynaptic 5-HT1A receptor stimulation. In addition, a possibility that subtypes of 5-HT receptors other than the 5-HT1A receptor, probably 5-HT7 receptor in the septum as well as postsynaptic 5-HT1A receptor in the hippocampus, are involved in the increased hippocampal ACh release induced by systemically administered 8-OH-DPAT is discussed. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:29:48