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Titolo:
DECREASED GLUCOSE-TRANSPORTER DENSITIES, RATE CONSTANTS AND GLUCOSE-UTILIZATION IN VISUAL STRUCTURES OF RAT-BRAIN DURING CHRONIC VISUAL DEPRIVATION
Autore:
DUELLI R; MAURER MH; KUSCHINSKY W;
Indirizzi:
UNIV HEIDELBERG,INST PHYSIOL,NEUENHEIMER FELD 326 D-69120 HEIDELBERG GERMANY
Titolo Testata:
Neuroscience letters
fascicolo: 1, volume: 250, anno: 1998,
pagine: 49 - 52
SICI:
0304-3940(1998)250:1<49:DGDRCA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNILATERAL ORBITAL ENUCLEATION; SYSTEM;
Keywords:
GLUT1; GLUT3; IMMUNOSTAINING; LOCAL CEREBRAL GLUCOSE UTILIZATION; AUTORADIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
R. Duelli et al., "DECREASED GLUCOSE-TRANSPORTER DENSITIES, RATE CONSTANTS AND GLUCOSE-UTILIZATION IN VISUAL STRUCTURES OF RAT-BRAIN DURING CHRONIC VISUAL DEPRIVATION", Neuroscience letters, 250(1), 1998, pp. 49-52

Abstract

The question was investigated whether local changes in glucose transporter densities and transport kinetics can occur when local cerebral glucose utilization (LCGU) is decreased in some brain structures. Unilateral visual deprivation was induced by monocular enucleation in 25 rats. After 1 week, the contralateral structures of the visual system were analyzed for (1) densities of glucose transporters Glut1 and Glut3 (immunoautoradiography), (2) LCGU (2-[C-14]deoxyglucose method) and (3) local rate constants (3-O-[C-14]methylglucose method). The ipsilateral structures served as controls. During chronic visual deprivation Glut1 and Glut3 densities, LCGU and rate constants were significantly decreased in some structures of the visual system and remained unchangedin others. These results indicate a moderate degree of downregulationof glucose transporters, LCGU and rate constants in the visual systemduring visual deprivation. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:19:00