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Titolo:
ABILITY OF ALTERNATIVE INDEXES OF INSULIN SENSITIVITY TO PREDICT CARDIOVASCULAR RISK - COMPARISON WITH THE MINIMAL MODEL
Autore:
HOWARD G; BERGMAN R; WAGENKNECHT LE; HAFFNER SM; SAVAGE PJ; SAAD MF; LAWS A; DAGOSTINO RB;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI,300 S HAWTHORNE RD WINSTON SALEM NC 27157 UNIV SO CALIF,DEPT PHYSIOL & PHARMACOL LOS ANGELES CA 00000 UNIV SO CALIF,DEPT MED LOS ANGELES CA 00000 UNIV TEXAS,DEPT MED SAN ANTONIO TX 78285 NHLBI BETHESDA MD 20892 STANFORD MED SCH PALO ALTO CA 00000
Titolo Testata:
Annals of epidemiology
fascicolo: 6, volume: 8, anno: 1998,
pagine: 358 - 369
SICI:
1047-2797(1998)8:6<358:AOAIOI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED GLUCOSE DISPOSAL; RESISTANCE ATHEROSCLEROSIS; DIABETES-MELLITUS; TOLERANCE TEST; HEART-DISEASE; HYPERTENSION; THICKNESS; CLAMP;
Keywords:
INSULIN RESISTANCE; CARDIOVASCULAR DISEASE; MEASUREMENT; RISK FACTORS; COHORT STUDY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
G. Howard et al., "ABILITY OF ALTERNATIVE INDEXES OF INSULIN SENSITIVITY TO PREDICT CARDIOVASCULAR RISK - COMPARISON WITH THE MINIMAL MODEL", Annals of epidemiology, 8(6), 1998, pp. 358-369

Abstract

INTRODUCTION: Although recognition of insulin sensitivity as a risk factor for cardiovascular disease is growing, a deeper understanding ofits role is impeded by the cost and complexity of currently availablemeasures. This report evaluates previously described alternative indices of insulin sensitivity with the goal of identifying a reliable, but logistically simpler, alternative. METHODS: Data from 1460 participants in the Insulin Resistance,Atherosclerosis Study (IRAS) were used to assess the proportion of the relationship between a recognized measure of insulin sensitivity (Bergman's S-1) and cardiovascular risk factors that is contained in each of nine alternative measures. RESULTS: Anumber of the alternative indices contained a substantial proportion of the information available in Bergman's S-1. The Galvin's index and the homeostasis model were most promising. However, there remained a significant amount of the information in Bergman's S-1 that was not contained in any of the alternative indices. DISCUSSION: There are simpler alternative indices of insulin sensitivity for use in epidemiological studies, but each alternative is associated with some loss of information. It may he possible that this loss can be overcome with an increased sample size; however, using the alternative indices may also confound the assessment of insulin sensitivity with other underlying factors (i.e., hyperinsulinemia). The alternative indices are not recommended for the clinical assessment of insulin sensitivity for an individual patient or subject. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:07:43