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Titolo:
COMPARISON OF THE IN-VITRO SUSCEPTIBILITY OF CLINICAL CYTOMEGALOVIRUSISOLATES TO CIDOFOVIR AND TO GANCICLOVIR
Autore:
HOUHOUFIDOUH N; MAZERON MC; DEWILDE A; THOUVENOT D; SCIEUX C; AISSA N; CARQUIN J; FREYMUTH F;
Indirizzi:
CHU BICHAT,VIROL LAB,46 RUE HENRI HUCHARD F-75877 PARIS 18 FRANCE CHU LARIBOISIERE PARIS FRANCE CHRU LILLE LILLE FRANCE CH LYON LYON FRANCE CHU ST LOUIS ST LOUIS FRANCE CHR REIMS REIMS FRANCE CHRU CAEN CAEN FRANCE
Titolo Testata:
Pathologie et biologie
fascicolo: 6, volume: 46, anno: 1998,
pagine: 420 - 422
SICI:
0369-8114(1998)46:6<420:COTISO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
FRE
Keywords:
CIDOFOVIR; GANCICLOVIR; RESISTANCE; CYTOMEGALOVIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
3
Recensione:
Indirizzi per estratti:
Citazione:
N. Houhoufidouh et al., "COMPARISON OF THE IN-VITRO SUSCEPTIBILITY OF CLINICAL CYTOMEGALOVIRUSISOLATES TO CIDOFOVIR AND TO GANCICLOVIR", Pathologie et biologie, 46(6), 1998, pp. 420-422

Abstract

Cidofovir (CDF) or Vistid(R) is a monophosphate nucleoside analogue that inhibits the DNA polymerase of herpes viruses including the cytomegalovirus (CMV). CDF is active on GCV-resistant strains with a mutation on the phosphotransferase gene (UL97). However, DNA polymerase gene mutations that induce resistance to GCV are responsible for cross-resistance to CDE Resistance phenotypes to GCV and CDF were determined for57 CMV strains isolated from blood and urine samples. Sixteen strainswere recovered after CDF therapy. Of the remaining 41 CDF-naive strains, 34 were susceptible and seven resistant to GCV Fifty percent inhibitory concentrations (IC50) for CDF were in the 0.2-2.6 CIM range for CDF-naive strains susceptible to GCV For GCV-resistant strains, IC50 values for CDF were less than or equal to 3 mu M for strains with a lowlevel of resistance to GCV (GCV IC50 < 30 mu M) and greater than or equal to 6 mu M for three of the five strains with a high level of resistance to GCV (GCV IC50 greater than or equal to 30 mu M).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 06:13:50