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Titolo:
EVIDENCE THAT OREXIGENIC EFFECTS OF MELANOCORTIN-4 RECEPTOR ANTAGONIST HS014 ARE MEDIATED BY NEUROPEPTIDE-Y
Autore:
KASK A; RAGO L; KORROVITS P; WIKBERG JES; SCHIOTH HB;
Indirizzi:
TARTU STATE UNIV,DEPT PHARMACOL,ULIKOOLI 18 EE-2400 TARTU ESTONIA UPPSALA UNIV,DEPT PHARMACEUT PHARMACOL,BMC S-75124 UPPSALA SWEDEN
Titolo Testata:
Biochemical and biophysical research communications (Print)
fascicolo: 2, volume: 248, anno: 1998,
pagine: 245 - 249
SICI:
0006-291X(1998)248:2<245:ETOEOM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; FOOD-INTAKE; RAT; HYPOTHALAMUS; EXPRESSION; RELEASE; FENFLURAMINE; SEROTONIN; BEHAVIOR; NPY;
Keywords:
MELANOCORTIN (MLC) RECEPTOR SUBTYPES; MC4 ANTAGONIST; CYCLIC MSH ANALOG; HS014; NEUROPEPTIDE Y; NEUROPEPTIDE Y1 RECEPTORS; 1229U91; FLUOXETINE; FOOD INTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
A. Kask et al., "EVIDENCE THAT OREXIGENIC EFFECTS OF MELANOCORTIN-4 RECEPTOR ANTAGONIST HS014 ARE MEDIATED BY NEUROPEPTIDE-Y", Biochemical and biophysical research communications (Print), 248(2), 1998, pp. 245-249

Abstract

Recent studies using melanocortin-4 receptor (MC4R) knockout mice andMC4R antagonists have shown that weakening of MC4R-ergic tone increases food intake and causes obesity. In this study, we used the newly discovered selective MC4R antagonist HS014 for increasing food intake infree-feeding rats and evaluated the effects of the NPY Y-1 receptor antagonist 1229U91 and the selective serotonin uptake inhibitor fluoxetine on this increased feeding behavior. 1229U91 (12 nmol, i.c.v.), which alone does not affect food intake, significantly attenuated the orexigenic effects of HS014, whereas 1 and 3 nmol doses of 1229U91 were ineffective. Fluoxetine, which has been shown to inhibit NPY release, inhibited spontaneous food intake and completely blocked the stimulation of food intake by HS014, These data suggest that feeding induced by weakening of the MC4R-ergic tone may be mediated through activation ofthe NPY-ergic system. This is the first report showing that physiological feeding response evoked by MC4R blockage is influenced by NPY signalling. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:10:08