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Titolo:
MINERALOCORTICOID RECEPTOR SPLICE VARIANTS IN DIFFERENT HUMAN TISSUES
Autore:
WICKERT L; WATZKA M; BOLKENIUS U; BIDLINGMAIER F; LUDWIG M;
Indirizzi:
UNIV BONN,DEPT CLIN BIOCHEM,SIGMUND FREUD STR 25 D-53105 BONN GERMANY
Titolo Testata:
European journal of endocrinology
fascicolo: 6, volume: 138, anno: 1998,
pagine: 702 - 704
SICI:
0804-4643(1998)138:6<702:MRSVID>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FISH GLUCOCORTICOID RECEPTOR; BINDING DOMAIN; IDENTIFICATION; CLONING; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
L. Wickert et al., "MINERALOCORTICOID RECEPTOR SPLICE VARIANTS IN DIFFERENT HUMAN TISSUES", European journal of endocrinology, 138(6), 1998, pp. 702-704

Abstract

The mineralocorticoid receptor (MR), a member of the steroid receptorfamily, acts as a transcription factor and mediates both aldosterone and cortisol effects. Aldosterone specificity in some tissues results from the inactivation of competing cortisol into cortisone by 11 beta-hydroxysteroid dehydrogenase. In other tissues MR and the glucocorticoid receptor show overlapping physiological effects or may act togetherby forming a heterodimer. An additional MR splice variant (MR+4) has been found in different mRNA samples from rat tissues and human white blood cells, thereby implying additional modes of MR-regulated effects. We therefore looked for the presence of these two MR-mRNA isoforms in human classical aldosterone target tissues and various other tissues. MR-mRNA was found in all samples investigated, thereby showing the expression of MR to be more abundant than has been observed thus far. In addition, the MR+4-mRNA variant was also found in all the tissues examined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:32:13