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Titolo:
MODELS OF THE ELONGATION CYCLE - AN EVALUATION
Autore:
SPAHN CMT; NIERHAUS KH;
Indirizzi:
MAX PLANCK INST MOL GENET,AG RIBOSOMEN,IHNESTR 73 D-14195 BERLIN GERMANY MAX PLANCK INST MOL GENET,AG RIBOSOMEN D-14195 BERLIN GERMANY
Titolo Testata:
Biological chemistry
fascicolo: 7, volume: 379, anno: 1998,
pagine: 753 - 772
SICI:
1431-6730(1998)379:7<753:MOTEC->2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFER-RNA-BINDING; ESCHERICHIA-COLI RIBOSOMES; ALLOSTERIC 3-SITE MODEL; AMINOACYL-TRANSFER-RNA; FLUORESCENCE ENERGY-TRANSFER; CODON-ANTICODON INTERACTION; PEPTIDE-BOND FORMATION; E-SITE; P-SITES; A-SITE;
Keywords:
ALLOSTERIC 3-SITE MODEL; ALPHA-EPSILON-E MODEL; A, P AND E SITES; HYBRID-SITE MODEL; PROTEIN SYNTHESIS; RIBOSOMES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
127
Recensione:
Indirizzi per estratti:
Citazione:
C.M.T. Spahn e K.H. Nierhaus, "MODELS OF THE ELONGATION CYCLE - AN EVALUATION", Biological chemistry, 379(7), 1998, pp. 753-772

Abstract

The central process for the transfer of the genetic information from the nucleic acid world into the structure of proteins is the ribosomalelongation cycle, where the sequence of codons is translated into thesequence of amino acids. The nascent polypeptide chain is elongated by one amino acid during the reactions of one cycle. Essentially, threemodels for the elongation cycle have been proposed. The allosteric three-site model and the hybrid-site model describe different aspects oftRNA binding and do not necessarily contradict each other. However, the alpha-epsilon model is not compatible with both models. The three models are evaluated in the light of recent results on the tRNA localization within the ribosome: the tRNAs of the elongating ribosome could be localized by two different techniques, viz. an advanced method of small-angle neutron scattering and cryo-electron microscopy. The best fit with the biochemical and structural data is obtained with the alpha-epsilon model.

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Documento generato il 04/04/20 alle ore 14:56:23