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Titolo:
RECENT ADVANCES ON LARGE ARTERIES IN HYPERTENSION
Autore:
SAFAR ME; LONDON GM; ASMAR R; FROHLICH ED;
Indirizzi:
HOP BROUSSAIS,DEPT INTERNAL MED,96 RUE DIDOT F-75674 PARIS 14 FRANCE HOP BROUSSAIS,INSERM,U337 F-75674 PARIS 14 FRANCE MANHES CTR FLEURY MEROGIS FRANCE ALTON OCHSNER MED FDN & OCHSNER CLIN NEW ORLEANS LA 70121
Titolo Testata:
Hypertension
fascicolo: 1, volume: 32, anno: 1998,
pagine: 156 - 161
SICI:
0194-911X(1998)32:1<156:RAOLAI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; CAROTID-ARTERY; BLOOD-PRESSURE; SYSTOLIC HYPERTENSION; MECHANICAL-PROPERTIES; HEART-RATE; STIFFNESS; DISTENSIBILITY; ENDOTHELIUM; PULSE;
Keywords:
HEMODYNAMICS; TRANSDUCTION; ARTERIES; VESSELS; VASCULAR REMODELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Safar et al., "RECENT ADVANCES ON LARGE ARTERIES IN HYPERTENSION", Hypertension, 32(1), 1998, pp. 156-161

Abstract

The most classic hemodynamic concept explaining the increased mean arterial pressure in hypertension reflects an increased total peripheralresistance dynamically and an increased wall-to-lumen ratio to suppress smaller arteries. However, a more current consideration takes into account not only that steady component but also the pulsatile component of blood pressure, a point that importantly modifies the traditionalhemodynamic definition. Whereas mean arterial pressure is almost constant along the arterial tree, the pulse pressure increases markedly from the more central to the peripheral arteries, indicating that in vivo each artery should be characterized according to its own blood pressure curve. This important concept implies major modifications in the methods used to investigate the relationships between mechanical factors and large artery structure and function. It therefore seems reasonable that in hypertension the large arteries should no longer be considered as passive conduits but rather in terms of their active behavioralresponse to the mechanical forces to which they are subjected. New investigational aspects in hypertension therefore now involve not only generic, cellular, and molecular mechanisms but also transductional hemodynamic mechanisms reflecting changing patterns in the extracellular matrix that influence structural remodeling of the vessels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:11:42