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Titolo:
EFFECTS OF HALOPERIDOL AND SCH 23390 ON ACOUSTIC STARTLE AND PREPULSEINHIBITION UNDER BASAL AND STIMULATED CONDITIONS
Autore:
SCHWARZKOPF SB; BRUNO JP; MITRA T;
Indirizzi:
UNIV ROCHESTER,SCH MED,DEPT PSYCHIAT,STRONG TIES CLIN,1650 ELMWOOD AVE ROCHESTER NY 14650 UNIV ROCHESTER,DEPT PSYCHIAT ROCHESTER NY 14650 OHIO STATE UNIV,DEPT PSYCHOL COLUMBUS OH 43210 OHIO STATE UNIV,DEPT PSYCHIAT COLUMBUS OH 43210
Titolo Testata:
Progress in neuro-psychopharmacology & biological psychiatry
fascicolo: 6, volume: 17, anno: 1993,
pagine: 1023 - 1036
SICI:
0278-5846(1993)17:6<1023:EOHAS2>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC-PATIENTS; RECEPTOR INTERACTION; NUCLEUS-ACCUMBENS; DOPAMINE; RATS; D1; APOMORPHINE; DISRUPTS; REFLEX; GENE;
Keywords:
ACOUSTIC STARTLE REFLEX; BASE-LINE STARTLE; DOPAMINE; D1 RECEPTOR; D2 RECEPTOR; PREPULSE INHIBITION; SYNERGISM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S.B. Schwarzkopf et al., "EFFECTS OF HALOPERIDOL AND SCH 23390 ON ACOUSTIC STARTLE AND PREPULSEINHIBITION UNDER BASAL AND STIMULATED CONDITIONS", Progress in neuro-psychopharmacology & biological psychiatry, 17(6), 1993, pp. 1023-1036

Abstract

1. Adult Sprague-Dawley rats underwent startle testing for assessmentof baseline startle amplitude and prepulse inhibition (PPI) of the startle reflex. 2. Animals were tested after administration of either: saline, a selective D1 dopamine (DA) receptor antagonist, a relatively selective D2 DA antagonist, or combined low dose D1 and D2 antagonists. 3. Changes due to antagonists were assessed with and without administration of the D1/D2 agonist apomorphine. 4. Testing without apomorphine stimulation showed that both D1 and D2 antagonists reduce baseline startle and enhance PPI. Further, the two antagonists exhibited a synergistic interaction. 5. Testing with apomorphine showed that D1 and D2antagonists reduce apomorphine-induced startle enhancement. Again, the two exhibited a synergistic interaction. 6. For PPI, the D2 but not D1 antagonist reduced the apomorphine effect. However, the D1 antagonist potentiated the effect of the D2 antagonist.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 22:21:23