Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NITRIC-OXIDE SYNTHASE INDUCTION IN LINES OF MACROPHAGES FROM DIFFERENT ANATOMICAL SITES
Autore:
PALLERONI AV; HAJOS S; WRIGHT RB; PALLERONI NJ;
Indirizzi:
RUTGERS STATE UNIV,CTR AGR MOL BIOL NEW BRUNSWICK NJ 08903 RUTGERS STATE UNIV,CTR AGR MOL BIOL NEW BRUNSWICK NJ 08903 UNIV BUENOS AIRES,FAC FARM & BIOQUIM,DEPT IMMUNOL BUENOS AIRES DF ARGENTINA HOFFMANN LA ROCHE INC,DEPT ONCOL NUTLEY NJ 07110
Titolo Testata:
Cellular and molecular biology
fascicolo: 3, volume: 44, anno: 1998,
pagine: 527 - 535
SICI:
0145-5680(1998)44:3<527:NSIILO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
L-ARGININE; RELAXING FACTOR; CELL-LINES; PERITONEAL-MACROPHAGES; MOUSE MACROPHAGES; ENDOTHELIAL-CELLS; CYTO-TOXICITY; SMOOTH-MUSCLE; MICE LACKING; RELEASE;
Keywords:
MACROPHAGE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; BIOLOGICAL RESPONSE MODIFIERS; INTERFERON GAMMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
A.V. Palleroni et al., "NITRIC-OXIDE SYNTHASE INDUCTION IN LINES OF MACROPHAGES FROM DIFFERENT ANATOMICAL SITES", Cellular and molecular biology, 44(3), 1998, pp. 527-535

Abstract

Induction of nitric oxide synthase (iNOS) and nitric oxide (NO) production have been demonstrated using three macrophage cell lines from different anatomical sites, which had been immortalized using a rapid and convenient procedure previously described. Lysis of tumor cells presumably was caused by NO accumulation in the supernatants of cultures of the three cell lines after induction with a mixture of recombinant murine interferon gamma (rMuIFN gamma) and lipopolysaccharide (LPS). Induction by these two biological response modifiers (BRM) caused lysis of tumor cells and was repressed by addition of 1 mu M (final concentration) of methyl-l-arginine (MMA) to the mixture during induction of the enzyme. Research using readily generated macrophage cell lines may facilitate clarify basic aspects of iNOS induction in these cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:26:40