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Titolo:
CYTOSKELETON-DEPENDENT INHIBITION OF THE ADP-RIBOSYL CYCLASE ACTIVITYOF CD38 IN THROMBIN-STIMULATED PLATELETS
Autore:
TORTI M; FESTETICS ET; BERTONI A; SINIGAGLIA F; BALDUINI C;
Indirizzi:
UNIV PAVIA,DEPT BIOCHEM,VIA BASSI 21 I-27100 PAVIA ITALY UNIV GENOA,INST BIOL CHEM I-16132 GENOA ITALY
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 431, anno: 1998,
pagine: 19 - 22
SICI:
0014-5793(1998)431:1<19:CIOTAC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACE ANTIGEN CD38; NAD GLYCOHYDROLASE; CALCIUM; MOLECULE; AGGREGATION; ACTIVATION; MEMBRANE; PATHWAY; CELLS;
Keywords:
ADP-RIBOSYL CYCLASE; CD38; CYTOSKELETON; PLATELET; CA2+ MOBILIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M. Torti et al., "CYTOSKELETON-DEPENDENT INHIBITION OF THE ADP-RIBOSYL CYCLASE ACTIVITYOF CD38 IN THROMBIN-STIMULATED PLATELETS", FEBS letters, 431(1), 1998, pp. 19-22

Abstract

Stimulation of human platelets with thrombin caused a 42% inhibition of the ADP-ribosyl cyclase activity of membrane CD38, This effect was mediated by the activation of the platelet thrombin receptor rather than by proteolysis of CD38, and was not due to a different distributionof the synthesised nucleotide or to a reduced accessibility of CD38 to the substrate. The inhibitory effect of thrombin required actin polymerisation and was not observed when interaction of CD38 with the cytoskeleton was prevented by cytochalasin IF. Finally, we analysed whether cADPR could play a role as a Ca2+-mobilising agent in human platelets. Using saponin-permeabilised cells,,ve found that unlike IP3, cADPR did not induce any release of Ca2+ from intracellular stores. These results indicate that the enzymatic activity of membrane CD38 can be modulated by platelet activation, and that the function of this glycoprotein is probably not related to Ca2+ mobilisation, (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:24:09