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Titolo:
DIETARY-INTAKE AND BLOOD-LEVELS OF LYCOPENE - ASSOCIATION WITH CERVICAL DYSPLASIA AMONG NON-HISPANIC, BLACK-WOMEN
Autore:
KANETSKY PA; GAMMON MD; MANDELBLATT J; ZHANG ZF; RAMSEY E; DNISTRIAN A; NORKUS EP; WRIGHT TC;
Indirizzi:
UNIV PENN,SCH MED,DEPT BIOSTAT & EPIDEMIOL PHILADELPHIA PA 19104 COLUMBIA UNIV,SCH PUBL HLTH,DIV EPIDEMIOL NEW YORK NY 10032 GEORGETOWN UNIV,SCH MED,VINCENT T LOMBARDI CANC RES CTR,DEPT MED WASHINGTON DC 20007 UNIV CALIF LOS ANGELES,SCH PUBL HLTH,DEPT EPIDEMIOL LOS ANGELES CA 00000 MEM SLOAN KETTERING CANC CTR,BREAST EXAMINAT CTR HARLEM NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,DEPT CLIN CHEM NEW YORK NY 10021 OUR LADY MERCY MED CTR BRONX NY 10466 COLUMBIA PRESBYTERIAN MED CTR,DEPT PATHOL,DIV OBSTET & GYNECOL PATHOLNEW YORK NY 10032
Titolo Testata:
Nutrition and cancer
fascicolo: 1, volume: 31, anno: 1998,
pagine: 31 - 40
SICI:
0163-5581(1998)31:1<31:DABOL->2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOD FREQUENCY QUESTIONNAIRE; VITAMIN-A; INTRAEPITHELIAL NEOPLASIA; BETA-CAROTENE; FOLIC-ACID; CANCER; RISK; PLASMA; FOLATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Kanetsky et al., "DIETARY-INTAKE AND BLOOD-LEVELS OF LYCOPENE - ASSOCIATION WITH CERVICAL DYSPLASIA AMONG NON-HISPANIC, BLACK-WOMEN", Nutrition and cancer, 31(1), 1998, pp. 31-40

Abstract

We examined whether elevated levels of retinoids, carotenoids, folate, and vitamin E protected against cervical dysplasia among non-Hispanic, black women. We enrolled 32 women with incident cervical dysplasia,including cervical intraepithelial neoplasia (CIN) I, CIN II, and CINIII/carcinoma in situ, and 113 control women with normal cervical cytology in a case-control study. Micronutrient levels were estimated from a food-frequency questionnaire (FFQ) and measured from blood samples. information on risk factors for cervical neoplasia was elicited by interview. Hybrid capture was used to determine infection with human papillomavirus. After adjustment for potential confounders, analysis of micronutrient levels estimated from the FFQ suggested that women in the upper tertile of lycopene and vitamin A intake were one-third (odds ratio = 0.32, 95% confidence interval = 0.8-1.3) and one-fourth (odds ratio = 0.24, 95% confidence interval = 0.05-1.2) as likely, respectively, to have dysplasia as women in the lower tertile. Borderline protective trends (p less than or equal to 0.10) were apparent. Elevated levels of serum lycopene also suggested some protection against dysplasia. Results were not significant at alpha = 0.05 because of the small number of case women enrolled. Overall, correlations between estimates from the FFQ and serum levels were pear. This study indicates that among black women, lycopene and perhaps vitamin A may play a protective role in the early stages of cervical carcinogenesis.

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Documento generato il 21/09/20 alle ore 15:12:41