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Titolo:
ASSESSMENT OF THE GLOBAL 2-STAGE METHOD TO EC50 DETERMINATION
Autore:
PATRONBIZET F; MENTRE F; GENTON M; THOMASHAIMEZ C; MACCARIO J;
Indirizzi:
UNIV PARIS 06,INSERM,U436,91 BD HOP F-75013 PARIS FRANCE INST RECH SERVIER,DEPT BIOSTAT F-92150 SURESNES FRANCE HOP LA PITIE SALPETRIERE,INSERM,U436 F-75013 PARIS FRANCE INSERM,U169 VILLEJUIF FRANCE
Titolo Testata:
Journal of pharmacological and toxicological methods
fascicolo: 2, volume: 39, anno: 1998,
pagine: 103 - 108
SICI:
1056-8719(1998)39:2<103:AOTG2M>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POPULATION PHARMACOKINETIC PARAMETERS; LAPLACES APPROXIMATION; EFFECTS MODELS; AFFINITY; EFFICACY;
Keywords:
CONCENTRATION-EFFECT RELATIONSHIP; PRECLINICAL PHARMACOLOGY; NONLINEAR MIXED EFFECTS MODEL; GLOBAL 2-STAGE METHOD; E-MAX MODEL; NONLINEAR REGRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
F. Patronbizet et al., "ASSESSMENT OF THE GLOBAL 2-STAGE METHOD TO EC50 DETERMINATION", Journal of pharmacological and toxicological methods, 39(2), 1998, pp. 103-108

Abstract

Preclinical studies of a new drug supply sets of concentration-effectobservations. For each experiment, EC50 is estimated through fitting of the E-max model. Naive pooling of these individual estimates, also called the Standard Two-Stage method (STS), is usually performed. A better combination is obtained by the Global Two-Stage method (GTS) which takes into account the variability of the nonlinear regression estimation errors. The performances of STS and GTS are compared on real andsimulated data. The results show that GTS performs better than STS interms of bias or RMSE, especially in case of poorly designed experiments. Degradation of the quality of STS results in simulations appears to be mainly due to some experiments that are usually rejected by experimenters. Such rejections are avoided when using GTS, which hence is particularly suitable for systematic treatment of this kind of data. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 11:42:46