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Titolo:
CHEMOPREVENTIVE EFFECTS OF NIMESULIDE, A SELECTIVE CYCLOOXYGENASE-2 INHIBITOR, ON THE DEVELOPMENT OF RAT URINARY-BLADDER CARCINOMAS INITIATED BY N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE
Autore:
OKAJIMA E; DENDA A; OZONO S; TAKAHAMA M; AKAI H; SASAKI Y; KITAYAMA W; WAKABAYASHI K; KONISHI Y;
Indirizzi:
NARA MED UNIV,CTR CANC,DEPT ONCOL PATHOL,840 SHIJO CHO KASHIHARA NARA634 JAPAN NARA MED UNIV,CTR CANC,DEPT ONCOL PATHOL KASHIHARA NARA 634 JAPAN NARA MED UNIV,DEPT UROL KASHIHARA NARA 634 JAPAN NATL CANC CTR,RES INST,CANC PREVENT DIV TOKYO 104 JAPAN
Titolo Testata:
Cancer research
fascicolo: 14, volume: 58, anno: 1998,
pagine: 3028 - 3031
SICI:
0008-5472(1998)58:14<3028:CEONAS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN G/H SYNTHASE-1; DIFFERENTIAL EXPRESSION; COLON-CANCER; CELL-LINES; CARCINOGENESIS; ASPIRIN; INDOMETHACIN; PIROXICAM; N-)4-(5-NITRO-2-FURYL)-2-THIAZOLYL>FORMAMIDE; PHARMACOKINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
E. Okajima et al., "CHEMOPREVENTIVE EFFECTS OF NIMESULIDE, A SELECTIVE CYCLOOXYGENASE-2 INHIBITOR, ON THE DEVELOPMENT OF RAT URINARY-BLADDER CARCINOMAS INITIATED BY N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE", Cancer research, 58(14), 1998, pp. 3028-3031

Abstract

The chemopreventive potential of a selective cyclooxygenase 2 inhibitor, nimesulide (NIM), against the development of rat superficial urinary bladder carcinomas after initiation with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was examined. Six-week-old Fischer 344 male rats were given 0.05% BBN in their drinking water for 8 weeks, followed by diets supplemented with 0, 100, 200, or 400 ppm NIM for 12 weeks, and they were then sacrificed. NIM decreased, in a dose-dependent manner, theincidence of transitional cell carcinoma (TCC) to 12 of 20 (60.0%), 8of 16 (50.0%), and 5 of 19 (26.3%) and the multiplicity of TCCs to 0.75 +/- 0.79, 0.56 +/- 0.63, and 0.37 +/- 0.78 per rat at 100, 200, and400 ppm, respectively, as compared with the BBN alone group values of18 of 20 (90.0%) and 2.35 +/- 1.23. NIM did not significantly. affectthe cell differentiation or invasiveness of TCCs. These results indicate clear chemopreventive potential of a selective cyclooxygenase-2 inhibitor against postinitiation development of superficial rat urinary bladder carcinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:53:07