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Titolo:
THROMBOGENIC PROPERTIES OF ANTIPHOSPHOLIPID ANTIBODIES DO NOT DEPEND ON THEIR BINDING TO BETA(2) GLYCOPROTEIN-1 (BETA(2)GP1) ALONE
Autore:
GHARAVI AE; PIERANGELI SS; GHARAVI EE; HUA T; LIU XW; BARKER JH; ANDERSON GH; HARRIS EN;
Indirizzi:
MOREHOUSE SCH MED,DEPT MICROBIOL & IMMUNOL,RM 1236,720 WESTVIEW DR SWATLANTA GA 30310 MOREHOUSE SCH MED,DEPT MICROBIOL & IMMUNOL ATLANTA GA 30310 MOREHOUSE SCH MED,DEPT PHYSIOL ATLANTA GA 30310 MOREHOUSE SCH MED,DEPT INTERNAL MED ATLANTA GA 30310 LOUISIANA STATE UNIV,DEPT MED NEW ORLEANS LA 00000 UNIV LOUISVILLE,DEPT SURG LOUISVILLE KY 00000 UNIV LOUISVILLE,DEPT PHYSIOL LOUISVILLE KY 00000
Titolo Testata:
Lupus
fascicolo: 5, volume: 7, anno: 1998,
pagine: 341 - 346
SICI:
0961-2033(1998)7:5<341:TPOAAD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-2-GLYCOPROTEIN-I APOLIPOPROTEIN-H; SYSTEMIC LUPUS-ERYTHEMATOSUS; ANTICARDIOLIPIN ANTIBODIES; HUMAN-PLATELETS; THROMBOSIS; CARDIOLIPIN; BETA(2)-GLYCOPROTEIN-I; AUTOANTIBODIES; IMMUNOGLOBULIN; ASSOCIATION;
Keywords:
ANTICARDIOLIPIN ANTIBODIES; ANTI-BETA(2)GP1 ANTIBODIES; ANTIPHOSPHOLIPID SYNDROME; MURINE MONOCLONAL ANTIBODIES; LUPUS ANTICOAGULANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A.E. Gharavi et al., "THROMBOGENIC PROPERTIES OF ANTIPHOSPHOLIPID ANTIBODIES DO NOT DEPEND ON THEIR BINDING TO BETA(2) GLYCOPROTEIN-1 (BETA(2)GP1) ALONE", Lupus, 7(5), 1998, pp. 341-346

Abstract

Immunization of mice with beta(2)glycoprotein 1 (beta(2)GP1) induces production of antiphospholipid (aPL) antibodies, which were shown to have thrombus enhancing properties in an experimental mouse model, indicating that these antibodies are thrombogenic in vivo. To determine whether the thrombogenic effect of murine antiphospholipid antibodies isdue to their aPL or their anti-beta(2)GP1 activity, we injected mice with murine monoclonal anticardiolipin (aCL) and anti-beta(2)GP1 antibodies. Effects of these antibodies on thrombus formation, was evaluated utilizing a mouse model which enables kinetics of thrombus;formationto be studied.The results of this study showed that the size of the thrombus in animals injected with murine aCL antibodies was larger thanthat in control groups. There was no difference in thrombus kinetics between anti-beta(2)GP1 injected mice and controls, suggesting that the thrombogenic effect of aPL antibodies is not related to their anti-beta(2)GPI activity alone. Mice receiving monoclonal antibodies with both aCL and anti-beta(2)GP1 activity, also increase thrombus size when compared with controls. These data indicate that murine aCL, but not anti-beta(2)GP1, antibodies are thrombogenic in vivo.

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Documento generato il 29/09/20 alle ore 10:11:21