Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DIMETHYL-SULFOXIDE (DMSO) IS MUTAGENIC FOR BACTERIAL MUTAGENICITY TESTER STRAINS
Autore:
HAKURA A; MOCHIDA H; YAMATSU K;
Indirizzi:
EISAI & CO LTD,DEPT DRUG SAFETY RES,1-3 TOKODAI,5 CHOME TSUKUBA IBARAKI 30026 JAPAN
Titolo Testata:
MUTATION RESEARCH
fascicolo: 3, volume: 303, anno: 1993,
pagine: 127 - 133
SICI:
0027-5107(1993)303:3<127:D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SALMONELLA-MICROSOME TEST; ORGANIC-SOLVENTS; ASSAY; COMPATIBILITY; CARCINOGENS; TYPHIMURIUM; INDUCTION; CHEMICALS; OPERONS; UMUDC;
Keywords:
DIMETHYL SULFOXIDE; MUTAGENICITY; SALMONELLA TYPHIMURIUM; ESCHERICHIA COLI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
A. Hakura et al., "DIMETHYL-SULFOXIDE (DMSO) IS MUTAGENIC FOR BACTERIAL MUTAGENICITY TESTER STRAINS", MUTATION RESEARCH, 303(3), 1993, pp. 127-133

Abstract

We used the Ames method with the modification of pre-incubation to evaluate the potential mutagenicity of DMSO. We performed the assays using nine different Ames Salmonella strains and Escherichia coli strainsWP2 and WP2uvrA. DMSO was found to be mutagenic for Salmonella typhimurium TA1537 and TA2637 (the latter strain being isogenic to TA1537 but carrying plasmid pKM101) and for E. coli WP2uvrA. The mutagenic activity of DMSO observed at a concentration of 33% was about 10 times higher than the background level (65 revertants induced) for TA1537 after20 min of incubation, where some lethal toxicity was observed. The mutagenicity of DMSO was observed in the presence and absence of rat liver S9 mix.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:32:48