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Titolo:
SEA CHROMOSOME LINKAGE OF CHICKEN AND DUCK TYPE-I INTERFERON GENES - FURTHER EVIDENCE OF EVOLUTIONARY CONSERVATION OF THE Z-CHROMOSOME IN BIRDS
Autore:
NANDA I; SICK C; MUNSTER U; KASPERS B; SCHARTL M; STAEHELI P; SCHMID M;
Indirizzi:
UNIV WURZBURG,BIOCTR,DEPT HUMAN GENET,HUBLAND D-97074 WURZBURG GERMANY UNIV WURZBURG,BIOCTR,DEPT HUMAN GENET D-97074 WURZBURG GERMANY UNIV FREIBURG,DEPT VIROL FREIBURG GERMANY UNIV MUNICH,DEPT ANIM PHYSIOL MUNICH GERMANY UNIV WURZBURG,DEPT PHYSIOL CHEM 1 WURZBURG GERMANY
Titolo Testata:
Chromosoma
fascicolo: 3, volume: 107, anno: 1998,
pagine: 204 - 210
SICI:
0009-5915(1998)107:3<204:SCLOCA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSITU HYBRIDIZATION; ESCHERICHIA-COLI; DNA; EXPRESSION; GAMMA; CELLS; TROPHOBLAST; FIBROBLAST; LEUKOCYTE; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
I. Nanda et al., "SEA CHROMOSOME LINKAGE OF CHICKEN AND DUCK TYPE-I INTERFERON GENES - FURTHER EVIDENCE OF EVOLUTIONARY CONSERVATION OF THE Z-CHROMOSOME IN BIRDS", Chromosoma, 107(3), 1998, pp. 204-210

Abstract

Type I interferons (IFNs) are a family of proteins that are predominantly expressed in response to viral infection. Two serologically distinct forms of type I IFN, designated ChIFN1 and ChIFN2, have recently been recognized in the chicken. ChIFN1 is encoded by a cluster of ten or more intronless genes, whereas ChIFN2, whose primary sequence is 57%identical, is encoded by a single intronless gene. By fluorescence insitu hybridization we now demonstrate that the genes for ChIFN1 and ChIFN2 are all located on the short arm of the chicken Z chromosome. This assignment was confirmed by results that showed that DNA from male (ZZ) chickens yielded approximately twofold stronger Southern blot signals with ChIFN1 and ChIFN2 hybridization probes than DNA from females(ZW). Attempts to determine differences in IFN production between male and female chickens failed owing to a high degree of variation in virus-induced IFN expression between individuals of both sexes. Sex linkage of IFN genes was also observed in domestic ducks: fluorescence in situ hybridization of duck metaphase chromosomes with a duck type I IFN probe was confined to the terminal region of the long arm of the Z chromosome. Thus, in contrast to mammals, which have their IFN genes onautosomes, birds have the type I IFN genes on the sex chromosome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 02:48:16