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Titolo:
LEVELS OF TAU-PHOSPHORYLATION AT DIFFERENT SITES IN ALZHEIMER-DISEASEBRAIN
Autore:
IKURA Y; KUDO T; TANAKA T; TANII H; GRUNDKEIQBAL I; IQBAL K; TAKEDA M;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT NEUROPSYCHIAT,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,DEPT NEUROPSYCHIAT SUITA OSAKA 565 JAPAN NEW YORK STATE INST BASIC RES DEV DISABIL STATEN ISL NY 10314
Titolo Testata:
NeuroReport
fascicolo: 10, volume: 9, anno: 1998,
pagine: 2375 - 2379
SICI:
0959-4965(1998)9:10<2375:LOTADS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIRED HELICAL FILAMENTS; PROTEIN-TAU; ABNORMAL PHOSPHORYLATION; MICROTUBULE-BINDING; MAP KINASE; SER(262);
Keywords:
ALZHEIMERS DISEASE; PAIRED HELICAL FILAMENT; PHOSPHORYLATION; TAU;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ikura et al., "LEVELS OF TAU-PHOSPHORYLATION AT DIFFERENT SITES IN ALZHEIMER-DISEASEBRAIN", NeuroReport, 9(10), 1998, pp. 2375-2379

Abstract

THE microtubule-associated protein tau is abnormally hyperphosphorylated in Alzheimer's disease (AD) brain. To date, 21 phosphorylated sites of tau have been identified. In the present study the levels of phosphorylation at Ser(199)/Ser(202), Thr(231)/Ser(235), Ser(262)/Ser(356)and Ser(196)/Ser(404) of tau in AD brain homogenate and its 100 000 xg supernatant were determined using radioimmuno-dot-blot assay. In homogenate, Ser(199)/Ser(202) and Ser(262)/Ser(356) were phosphorylated to similar level and were more phosphorylated than Thr(231) Or Ser(396)/Ser(404). In supernatant, there was no significant difference in phosphorylated tau level among the investigated sites except for Thr(231)/Ser(235) which was least phosphorylated. These results suggest that Ser(199)/Ser(202) and Ser(262)/Ser(356) are major sites of phosphorylation of tan in AD brain. NeuroReport 9: 2375-2379 (C) 1998 Rapid Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 18:39:02