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Titolo:
THE PATHOPHYSIOLOGY OF PRIMARY DYSTONIA
Autore:
BERARDELLI A; ROTHWELL JC; HALLETT M; THOMPSON PD; MANFREDI M; MARSDEN CD;
Indirizzi:
UNIV ROMA LA SAPIENZA,DIPARTIMENTO SCI NEUROL,VIALE UNIV 30 I-00185 ROME ITALY MEDITERRANEAN NEUROL INST POZZILLI IS ITALY NATL HOSP NEUROL & NEUROSURG,HUMAN MOVEMENT & BALANCE UNIT,NEUROL INST LONDON WC1N 3BG ENGLAND NINCDS,HUMAN MOTOR CONTROL SECT,NIH BETHESDA MD 20892 ROYAL ADELAIDE HOSP,UNIV DEPT MED ADELAIDE SA 5000 AUSTRALIA
Titolo Testata:
Brain (Print)
, volume: 121, anno: 1998,
parte:, 7
pagine: 1195 - 1212
SICI:
0006-8950(1998)121:<1195:TPOPD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC TORSION DYSTONIA; SOMATOSENSORY-EVOKED-POTENTIALS; MOVEMENT-RELATED POTENTIALS; MASSETER INHIBITORY REFLEX; HUMAN MOTOR CORTEX; F-18 DOPA UPTAKE; RECIPROCAL INHIBITION; SPASMODIC TORTICOLLIS; WRITERS CRAMP; BLINK REFLEX;
Keywords:
DYSTONIA; CORTICAL AREAS; SPINAL CORD; BRAIN-STEM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
117
Recensione:
Indirizzi per estratti:
Citazione:
A. Berardelli et al., "THE PATHOPHYSIOLOGY OF PRIMARY DYSTONIA", Brain (Print), 121, 1998, pp. 1195-1212

Abstract

Go-contraction and overflow of EMG activity of inappropriate muscles are typical features of all dystonic movements whether voluntary or involuntary. Voluntary movements are slow and more variable than normal,and there is particular difficultly switching between component movements of a complex task, Reduced spinal cord and brainstem inhibition is common to many reflex studies (long-latency reflexes, cranial reflexes and reciprocal inhibition), These reflex abnormalities may contribute to the difficulties in voluntary movements but cannot be causal as they can occur outside the clinically involved territory, Clinical andneurophysiological studies have emphasized the possible role of sensory feedback in the generation of dystonic movements, Abnormalities of cortical and basal ganglia function have been described in functional imaging and neurophysiological studies of patients with dystonia and in animal models of primary dystonia, Studies of cortical function haveshown reduced preparatory activity in the EEG before the onset of voluntary movements, whilst magnetic brain stimulation has revealed changes in motor cortical excitability, Functional imaging of the brain in primary dystonia has suggested reduced pallidal inhibition of the thalamus with consequent overactivity of medial and prefrontal cortical areas and underactivity of the primary motor cortex during movements. These findings are supported by preliminary neuronal recordings from theglobus pallidus and the thalamus at the time of stereotaxic surgery in patients with dystonia, All this evidence suggests that primary dystonia results from a functional disturbance of the basal ganglia, particularly in the striatal control of the globus pallidus (and substantianigra pars reticulata), This causes altered thalamic control of cortical motor planning and executive areas, and abnormal regulation of brainstem and spinal cord inhibitory interneuronal mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 08:02:42