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Titolo:
PHOSPHORYLATION REGULATES CALPAIN-MEDIATED TRUNCATION OF GLUTAMATE IONOTROPIC RECEPTORS
Autore:
BI RF; BI XN; BAUDRY M;
Indirizzi:
UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089 UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089
Titolo Testata:
Brain research
fascicolo: 1, volume: 797, anno: 1998,
pagine: 154 - 158
SICI:
0006-8993(1998)797:1<154:PRCTOG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; PROTEIN-KINASE-II; HYPOTHESIS; EXPRESSION;
Keywords:
CALPAIN; GLUTAMATE; RECEPTOR; PHOSPHORYLATION; PLASTICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R.F. Bi et al., "PHOSPHORYLATION REGULATES CALPAIN-MEDIATED TRUNCATION OF GLUTAMATE IONOTROPIC RECEPTORS", Brain research, 797(1), 1998, pp. 154-158

Abstract

Pre-incubation of synaptic membranes with phosphatase inhibitors significantly reduces the extent of calpain-mediated truncation of both GluR1 and NR2 subunits of AMPA and NMDA receptors, respectively. The same treatment did not modify calpain-mediated truncation of spectrin. These results might have important implications for mechanisms of synaptic plasticity as the balance of kinase/phosphatase activity and calpain has been proposed to regulate synaptic efficacy at glutamatergic synapses. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:49:13