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Titolo:
DESMOGLEIN IN MULTIPLE SELF-HEALING SQUAMOUS EPITHELIOMA OF FERGUSON-SMITH - COMPARISON OF STAINING PATTERNS WITH ACTINIC KERATOACANTHOMA AND SQUAMOUS-CELL CARCINOMA OF THE SKIN
Autore:
KRUNIC AL; GARROD DR; HUNTER JAA; CLARK RE;
Indirizzi:
UNIV MANCHESTER,SCH BIOL SCI,EPITHELIAL MORPHOGENESIS RES GRP,3-239 STOPFORD BLDG,OXFORD RD MANCHESTER M13 9PT LANCS ENGLAND UNIV MANCHESTER,SCH BIOL SCI,EPITHELIAL MORPHOGENESIS RES GRP MANCHESTER M13 9PT LANCS ENGLAND DUKE UNIV,MED CTR,DIV DERMATOL DURHAM NC 27710 UNIV EDINBURGH,DEPT DERMATOL EDINBURGH EH8 9YL MIDLOTHIAN SCOTLAND
Titolo Testata:
Archives of dermatological research
fascicolo: 6, volume: 290, anno: 1998,
pagine: 319 - 324
SICI:
0340-3696(1998)290:6<319:DIMSSE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BCL-2 EXPRESSION; DESMOSOMES; HETEROZYGOSITY; ASSOCIATION; JUNCTIONS; DIAGNOSIS;
Keywords:
DESMOGLEIN; MULTIPLE SELF-HEALING SQUAMOUS CELL EPITHELIOMA; 32-2B MONOCLONAL ANTIBODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A.L. Krunic et al., "DESMOGLEIN IN MULTIPLE SELF-HEALING SQUAMOUS EPITHELIOMA OF FERGUSON-SMITH - COMPARISON OF STAINING PATTERNS WITH ACTINIC KERATOACANTHOMA AND SQUAMOUS-CELL CARCINOMA OF THE SKIN", Archives of dermatological research, 290(6), 1998, pp. 319-324

Abstract

Background: Multiple self-healing squamous cell epithelioma of the skin (MSSE) is the most common variant of multiple keratoacanthoma, Although the morphology of the lesions in MSSE is similar to classical actinic keratoacanthoma (KA), several distinctive features in clinical presentation and histology have been emphasized. Desmosomes have been shown to he downregulated in certain types of carcinoma. Desmogleins (Dsg) are transmembrane desmosomal glycoproteins that exist as three isoforms, Dsg markers have been found to be reduced or absent in squamous cell carcinoma (SCC) but preserved in KA, Objective: This study was designed to determine the pattern of Dsg staining in MSSE, Methods: Eight tumors from two female patients with MSSE were stained with the anti-desmoglein monoclonal antibody 32-2B, which recognizes Dsg1 and Dsg3,Results: All eight tumors showed uniform pericellular Dsg staining throughout the nonkeratinized layers of the neoplastic epithelium. This pattern is entirely similar to that observed in actinic KA, normal epidermis or follicular epithelium. Conclusion: Despite the differences, uniform preservation of Dsg seems to be the invariable feature of bothMSSE and KA. Further studies are necessary to evaluate this antibody in routine dermatopathology of MSSE and SCC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:18:48