Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INCIDENCE OF TUBERCULOSIS AFTER BONE-MARROW TRANSPLANTATION IN A SINGLE-CENTER FROM TURKEY
Autore:
ARSLAN O; GURMAN G; DILEK I; OZCAN M; KOC H; ILHAN O; AKAN H; KONUK N; UYSAL A; BEKSAC M;
Indirizzi:
ANKARA UNIV,IBNI SINA HOSP,DEPT HEMATOL ONCOL,BONE MARROW TRANSPLANTAT UNIT TR-06100 ANKARA TURKEY
Titolo Testata:
Haematologia
fascicolo: 1, volume: 29, anno: 1998,
pagine: 59 - 62
SICI:
0017-6559(1998)29:1<59:IOTABT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFECTIONS; BMT;
Keywords:
STEM CELL TRANSPLANTATION; TUBERCULOSIS; IMMUNOSUPPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
O. Arslan et al., "INCIDENCE OF TUBERCULOSIS AFTER BONE-MARROW TRANSPLANTATION IN A SINGLE-CENTER FROM TURKEY", Haematologia, 29(1), 1998, pp. 59-62

Abstract

Tuberculosis (TB) is generally seen in immunodeficient states and itsincidence would be expected to increase after hematopoietic stem celltransplantation (SCT), particularly in the allogeneic setting. However, recent reports from developed countries did not support this hypothesis. Turkey is one of the countries where the disease is endemic. Over a period of 10 years two cases of TB among 120 allogeneic and 65 autologous bone marrow or peripheral blood SCT were encountered. The first patient was a 42-year-old male with acute nonlymphoblastic leukemia (ANLL) who underwent allogeneic SCT from his HLA-identical sister in first remission. His early post transplant period was unremarkable and showed no clinical acute or chronic graft versus host disease (GVHD). His chest X-ray and CT scan revealed alveolar infiltrate of the left apical lobe one year after the procedure and sputum showed acid-fast bacilli, later identified as Mycobacterium tuberculosis. He was put on combination chemotherapy. He is now well and disease-free 30 months after transplant with no complaints of pulmonary TB. The second patient with chronic phase CML underwent allogeneic peripheral SCT from his HLA-identical sister. He suffered from,grade II acute and extensive chronic GVHD partially treated with immunosuppressive therapy. He showed pulmonary TB 15 months after transplantation. He is still on combinationchemotherapy. Although our numbers are small, the annual incidence ofTB after SCT is 1.1% (2/185) which is nearly 30 to 40 times higher than the incidence of TB in the general Turkish population. In other words, an immunosuppressive state after allogeneic SCT seems to increase the risk of TB in Turkey. In conclusion, TB should be considered in the differential diagnosis of unexplained infections after SCT, especially in countries, where the disease is endemic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:47:27