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Titolo:
THE RELATIONSHIP BETWEEN PLASMA MHPG AND NE - EMPLOYING REGRESSION-MODELS IN ESTIMATING CENTRALLY DERIVED MHPG AND PERIPHERAL NE TURNOVER RATE IN PANIC DISORDER
Autore:
GURGUIS GNM; UHDE TW;
Indirizzi:
NIMH,BIOL PSYCHIAT BRANCH,ANXIETY & AFFECT DISORDERS SECT BETHESDA MD20892
Titolo Testata:
Journal of Psychiatric Research
fascicolo: 1, volume: 32, anno: 1998,
pagine: 11 - 17
SICI:
0022-3956(1998)32:1<11:TRBPMA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
3-METHOXY-4-HYDROXYPHENYLETHYLENE GLYCOL MHPG; ALPHA-2-ADRENERGIC RECEPTOR-BINDING; GENERALIZED ANXIETY DISORDER; NORADRENERGIC FUNCTION; CEREBROSPINAL-FLUID; HEALTHY-SUBJECTS; HEART-RATE; NOREPINEPHRINE METABOLISM; ELECTROCHEMICAL DETECTION; ANTIANXIETY TREATMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
G.N.M. Gurguis e T.W. Uhde, "THE RELATIONSHIP BETWEEN PLASMA MHPG AND NE - EMPLOYING REGRESSION-MODELS IN ESTIMATING CENTRALLY DERIVED MHPG AND PERIPHERAL NE TURNOVER RATE IN PANIC DISORDER", Journal of Psychiatric Research, 32(1), 1998, pp. 11-17

Abstract

Studies investigating the role of the noradrenergic system in the pathophysiology of anxiety have focused on measuring plasma 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) levels. Fewer studies have examined norepinephrine levels. Basal plasma norepinephrine and free MHPG levels were simultaneously measured in 33 normal controls and 20 panic disorder (PD) patients. Norepinephrine levels were similar in patients andcontrols, but MHPG levels were significantly lower in patients (13.34+/- 3.22 vs 18.37 +/- 4.49 pmol ml(-1), p < 0.0001). Norepinephrine correlated significantly with plasma MHPG levels in controls (r=0.538, p<0.0001) and patients (r=0.645, p<0.002). Patients had a trend towarda lower y-intercept than controls, suggesting a lower contribution bythe CNS to MHPG pool plasma levels (9.18 vs 12.51,p<0.08). Norepinephrine turnover rate was similar in patients and controls. We propose that the dysregulation in the noradrenergic system in PD may be akin to animal studies of acute-on-top-of-chronic stress paradigms, whereby chronic stress results in normal or decreased basal NE turnover and sensitized responses to recurrent stresses. (C) 1998 Elsevier Science Ltd. All rights reserved.

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Documento generato il 08/04/20 alle ore 22:38:30