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Titolo:
INTRANUCLEAR TRAFFICKING AND GENE TARGETING BY MEMBERS OF THE STEROIDNUCLEAR RECEPTOR SUPERFAMILY/
Autore:
HAGER GL; SMITH CL; FRAGOSO G; WOLFORD R; WALKER D; BARSONY J; HTUN H;
Indirizzi:
NCI,LAB RECEPTOR BIOL & GENE EXPRESS,BLDG 41,ROOM B602 BETHESDA MD 20892 NIDDK,LAB CELLULAR BIOCHEM & BIOL,NIH BETHESDA MD 20892
Titolo Testata:
Journal of steroid biochemistry and molecular biology
fascicolo: 1-6, volume: 65, anno: 1998,
pagine: 125 - 132
SICI:
0960-0760(1998)65:1-6<125:ITAGTB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOCORTICOID RESPONSE ELEMENT; TRANSCRIPTION FACTOR ACCESS; TUMOR VIRUS PROMOTER; MMTV PROMOTER; IN-VIVO; SACCHAROMYCES-CEREVISIAE; HISTONE ACETYLATION; NUCLEOSOMAL DNA; CHROMATIN; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
G.L. Hager et al., "INTRANUCLEAR TRAFFICKING AND GENE TARGETING BY MEMBERS OF THE STEROIDNUCLEAR RECEPTOR SUPERFAMILY/", Journal of steroid biochemistry and molecular biology, 65(1-6), 1998, pp. 125-132

Abstract

Upon binding to regulatory elements in mammalian chromosomes, steroidreceptors induce specific transitions in the nucleoprotein structure of the template. These transitions reflect, in part, the reorganization of chromatin structure to permit interaction of secondary factors with target sequences in promoter regulatory regions. Steroid receptors represent a class of transcriptional activators that are able to interact with repressed nucleoprotein templates and recruit necessary activities for chromatin remodeling. The ligand-induced movement of nuclearreceptors from inactive states, either in the cytoplasm or in the nucleus, to productive interactions with chromatin is complex and likely reflects the interaction with multiple protein complexes and subcellular structures. Regulation of gene expression by nuclear receptors is thus mediated through the subcellular distribution of inactive receptors, the redistribution of activated receptor complexes to appropriate nuclear domains, the reorganization of chromatin structures for interaction with soluble components of the nucleoplasm, and direct protein-protein contacts between receptors and the basal transcription apparatus. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:01:20