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Titolo:
CHANGES WITH AGING IN THE MODULATION OF MURINE LYMPHOCYTE CHEMOTAXIS BY CCK-8S, GRP AND NPY
Autore:
MEDINA S; DELRIO M; VICTOR VM; HERNANZ A; DELAFUENTE M;
Indirizzi:
UNIV COMPLUTENSE MADRID,FAC BIOL SCI,DEPT ANIM PHYSIOL E-28040 MADRIDSPAIN UNIV COMPLUTENSE MADRID,FAC BIOL SCI,DEPT ANIM PHYSIOL E-28040 MADRIDSPAIN HOSP LA PAZ,SERV BIOCHEM MADRID 28230 SPAIN
Titolo Testata:
Mechanism of ageing and development
fascicolo: 2-3, volume: 102, anno: 1998,
pagine: 249 - 261
SICI:
0047-6374(1998)102:2-3<249:CWAITM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIN-RELEASING PEPTIDE; PROTEIN-KINASE-C; PERITONEAL MACROPHAGE FUNCTIONS; NEUROPEPTIDE-Y; NEUROMEDIN-C; PHAGOCYTIC FUNCTION; SUBSTANCE-P; GUINEA-PIG; BOMBESIN; PROLIFERATION;
Keywords:
AGING; MOBILITY; CHEMOTAXIS; LYMPHOCYTE; NEUROPEPTIDES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
S. Medina et al., "CHANGES WITH AGING IN THE MODULATION OF MURINE LYMPHOCYTE CHEMOTAXIS BY CCK-8S, GRP AND NPY", Mechanism of ageing and development, 102(2-3), 1998, pp. 249-261

Abstract

The general immunodepression found in ageing organisms may be relatedto changes in the neuroimmune network. In the present study, the migration capacity of lymphocytes from BALB/c mice of three different ages: young (12 +/- 2 weeks), adult (24 +/- 2 weeks) and old (72 +/- 2 weeks), has been assayed in vitro in response to three neuropeptides: sulfated cholecystokinin octapeptide (CCK-8s), gastrin-releasing peptide (GRP) and neuropeptide Y (NPY) in a physiological range of concentrations (10(-8)-10(-12) M). The capacity of migration to a chemical gradient or chemotaxis was studied by the Boyden's technique using f-met-leu-phe at 10(-8) M as chemoattractant. The results show a different response of lymphocytes to the different neuropeptides, as wells as to age, concentrations and locations studied. However, some similarities were found, for instance the three neuropeptides inhibited chemotaxis in thymus. The stimulatory effects that GRP and NPY exerted in young and adult mice were not observed in old animals. CCK-8s inhibited the chemotaxis in every organ studied, with the effect being more striking in old mice. Our conclusion is that stimulatory effects of the neuropeptides disappear or become inhibitory with ageing. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:42:42