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Titolo:
AUTOIMMUNE HEPATITIS ASSOCIATED WITH FIBRATE TREATMENT
Autore:
GANNECARRIE N; DELEUSSE A; GUETTIER C; CASTERA L; LEVECQ H; BERTRAND HJ; PLUMET Y; TRINCHET JC; BEAUGRAND M;
Indirizzi:
HOP JEAN VERDIER,SERV HEPATOGASTROENTEROL,AVE 14 JUILLET F-93143 BONDY FRANCE HOP JEAN VERDIER,SERV ANAT PATHOL F-93143 BONDY FRANCE CTR HOSP CHARTRES,SERV HEPATOGASTROENTEROL CHARTRES FRANCE CLIN JOCKEYS,SERV HEPATOGASTROENTEROL CHANTILLY FRANCE CTR HOSP TROYES,SERV HEPATOGASTROENTEROL TROYES FRANCE
Titolo Testata:
Gastroenterologie clinique et biologique
fascicolo: 5, volume: 22, anno: 1998,
pagine: 525 - 529
SICI:
0399-8320(1998)22:5<525:AHAWFT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
FRE
Soggetto:
CHRONIC ACTIVE HEPATITIS; AUTOIMMUNE-HEPATITIS; SUSCEPTIBLE INDIVIDUALS; FENOFIBRATE; TRIGGER; INJURY; VIRUS;
Keywords:
FIBRATES; TOXIC HEPATITIS; AUTOIMMUNE HEPATITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
N. Gannecarrie et al., "AUTOIMMUNE HEPATITIS ASSOCIATED WITH FIBRATE TREATMENT", Gastroenterologie clinique et biologique, 22(5), 1998, pp. 525-529

Abstract

Aim. - Long term treatment by fibrates could induce chronic hepatitisassociated with auto-antibodies. The aim of this study was to assess the features of this hepatitis. Methods. - Baseline clinical and biological features, and liver biopsy in 5 patients with fibrate-induced chronic hepatitis were studied, as well as their outcome. Results. - At enrollment, patients (4 men, mean age 65 years) had highly (n = 3) or mildly (n = 2) increased serum aminotransferase activity, hypergammaglobulinemia and high titers of anti-nuclear antibodies (with homogenousfluorescence in 3 cases). Liver biopsies demonstrated a lympho-plasmocytic infiltrate in all cases. Hepatocellular necrosis was multilobular in 2 cases, and mild to moderate, located in lobular and periportal areas in 3 cases. Cirrhosis was found at presentation in 3 cases and developed within a few months in the 2 other patients. After discontinuation of fibrates, aminotransferase activity normalized within 6 weekseither spontaneously (n = 3) or under immunosuppressive treatment (n = 2). Immunosuppression was rapidly withdrawn in 2 patients (< 18 months) without relapse, while one patient Mas treated for 4 years becauseof relapse after early withdrawal. A second liver biopsy performed 6 months after discontinuation of fibrates in an untreated-patient showed no inflammation or necrosis. Conclusion. - These observations suggest that fibrates could trigger chronic liver disease resembling type I auto-immune chronic hepatitis, which resolves after drug withdrawal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/02/20 alle ore 08:17:20