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Titolo:
DISTRIBUTION OF OPIOID PEPTIDE GENE-EXPRESSION IN THE LIMBIC SYSTEM OF FAWN-HOODED (ALCOHOL-PREFERRING) AND WISTAR-KYOTO (ALCOHOL-NON-PREFERRING) RATS
Autore:
COWEN MS; REZVANI A; JARROTT B; LAWRENCE AJ;
Indirizzi:
MONASH UNIV,DEPT PHARMACOL CLAYTON VIC 3168 AUSTRALIA UNIV N CAROLINA,SCH MED,SKIPPER BOWLES CTR ALCOHOL STUDIES CHAPEL HILL NC 27599
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 796, anno: 1998,
pagine: 323 - 326
SICI:
0006-8993(1998)796:1-2<323:DOOPGI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRODYNORPHIN MESSENGER-RNA; BRAIN; CONSUMPTION; PREFERENCE; NALTREXONE; DEPENDENCE;
Keywords:
IN SITU HYBRIDIZATION HISTOCHEMISTRY; REINFORCEMENT; PREPRODYNORPHIN; PREPROENKEPHALIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Cowen et al., "DISTRIBUTION OF OPIOID PEPTIDE GENE-EXPRESSION IN THE LIMBIC SYSTEM OF FAWN-HOODED (ALCOHOL-PREFERRING) AND WISTAR-KYOTO (ALCOHOL-NON-PREFERRING) RATS", Brain research, 796(1-2), 1998, pp. 323-326

Abstract

Preprodynorphin and preproenkephalin mRNA expression was examined in the CNS of two rat strains, the alcohol-preferring Fawn-Hooded (FH) and the alcohol-non-preferring Wistar-Kyoto (WKY), using in situ hybridisation histochemistry. Relative to the WKY, the FH showed significantly lower levels of preproenkephalin mRNA in the striatum and nucleus accumbens (-24% and -17% respectively), but a higher level of preprodynorphin mRNA in the hippocampus (+33%). The depressed level of preproenkephalin mRNA in the nucleus accumbens may be implicated in alcohol-seeking behaviour. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:54:44