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Titolo:
A NOVEL AND EFFICIENT SYNTHESIS OF 14-ALKOXY-SUBSTITUTED INDOLOFUROMORPHINANS AND BENZOFUROMORPHINANS IN THE SERIES OF SELECTIVE DELTA-OPIOID RECEPTOR ANTAGONISTS
Autore:
SCHMIDHAMMER H; SCHWARZ P; WEI ZY;
Indirizzi:
INNSBRUCK UNIV,INST PHARMACEUT CHEM,INNRAIN 52A A-6020 INNSBRUCK AUSTRIA ASTRA RES CTR MONTREAL,DEPT CHEM ST LAURENT PQ H4S 1Z9 CANADA
Titolo Testata:
Helvetica chimica acta
fascicolo: 7, volume: 81, anno: 1998,
pagine: 1215 - 1222
SICI:
0018-019X(1998)81:7<1215:ANAESO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOLOGICAL EVALUATION; 14-ALKOXYMORPHINANS; NALTRINDOLE; AGONISTS; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
H. Schmidhammer et al., "A NOVEL AND EFFICIENT SYNTHESIS OF 14-ALKOXY-SUBSTITUTED INDOLOFUROMORPHINANS AND BENZOFUROMORPHINANS IN THE SERIES OF SELECTIVE DELTA-OPIOID RECEPTOR ANTAGONISTS", Helvetica chimica acta, 81(7), 1998, pp. 1215-1222

Abstract

A novel and more efficient synthesis of 14-alkoxy-substituted indolo-and benzofuro-morphinans in three steps starting from either naltrindole (1) or naltriben (2), using methoxymethyl or silyl protecting groups, is reported. The 14-O-alkyl group is introduced at the penultimatestep of the procedure. This is an additional advantage of the described procedure since the late introduction of the 14-O-alkyl group makesit much easier to produce a greater diversity of 14-alkoxy derivatives in this series of delta opioid receptor antagonists. Thus, compounds14-19, 20-25, and 27-29 were synthesized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 17:02:03