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Titolo:
ENDOCRINE STRESS-RESPONSE AND ABNORMAL-DEVELOPMENT IN CARP (CYPRINUS-CARPIO) LARVAE AFTER EXPOSURE OF THE EMBRYOS TO PCB-126
Autore:
STOUTHART XJHX; HUIJBREGTS MAJ; BALM PHM; LOCK RAC; BONGA SEW;
Indirizzi:
CATHOLIC UNIV NIJMEGEN,FAC SCI,DEPT ANIM PHYSIOL,TOERNOOIVELD NL-6525ED NIJMEGEN NETHERLANDS
Titolo Testata:
Fish physiology and biochemistry
fascicolo: 4, volume: 18, anno: 1998,
pagine: 321 - 329
SICI:
0920-1742(1998)18:4<321:ESAAIC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TILAPIA OREOCHROMIS-MOSSAMBICUS; LIFE-STAGE MORTALITY; TROUT ONCORHYNCHUS-MYKISS; RAINBOW-TROUT; LAKE TROUT; SALVELINUS-NAMAYCUSH; STIMULATING HORMONE; INTERRENAL FUNCTION; 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN; CORTISOL;
Keywords:
FISH; EARLY DEVELOPMENT; PCB 126; ACTH; A-MSH; CORTISOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
X.J.H.X. Stouthart et al., "ENDOCRINE STRESS-RESPONSE AND ABNORMAL-DEVELOPMENT IN CARP (CYPRINUS-CARPIO) LARVAE AFTER EXPOSURE OF THE EMBRYOS TO PCB-126", Fish physiology and biochemistry, 18(4), 1998, pp. 321-329

Abstract

To investigate whether PCB 126 exposure during embryonic development induces an endocrine stress response in larval carp, eggs were exposed, immediately after fertilization, for 48 h to water containing 0.01% ethanol (vehicle-control), 10(-11), 10(-10) or 10(-9) mol l(-1) PCB in0.01% ethanol. Eggs incubated in water served as controls. After transfer to PCB-free water, mortality, the incidence of yolk-sac and pericardial oedema, wet and dry weight, rate of skin pigmentation, and whole-body contents of the stress hormones ACTH, a-MSH and cortisol were determined at 48, 96, 144, 168, 192 and 216 h postfertilization. Exceptfor the dry weight, all parameters of animals exposed to 10(-10) and 10(-9) mol l(-1) PCB increased in a concentration-related manner. However, these changes became evident only at 144 h postfertilization, i.e. after resorption of the yolk-sac. Swelling of the yolk sac and pericardium occurred, and whole-body ACTH, alpha-MSH and cortisol levels increased. Although animals exposed to 10(-10) and 10(-9) mol l(-1) PCB displayed stable but elevated whole-body ACTH and alpha-MSH levels until 216 h, whole-body cortisol concentrations gradually decreased from 168 h post-fertilization, and were significantly below control values at 216 h post-fertilization. Exposure of the carp embryos to 10(-11) mol l(-1) PCB only increased whole-body alpha-MSH levels. Increased whole-body ACTH and cortisol levels indicate that PCB induces a stress response in carp larvae, possibly mediated by a disturbed hydromineral balance (oedema). We further suggest that the PCB-stimulated body pigmentation is mediated by a stimulation of alpha-MSH secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:32:37