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Titolo:
THE NATURAL-HISTORY OF THE IMMUNE-RESPONSE TO EXOGENOUS FACTOR-VIII IN SEVERE HEMOPHILIA-A
Autore:
SCANDELLA D; MONDORF W; KLINGE J;
Indirizzi:
AMER RED CROSS,HOLLAND LAB,15601 CRABBS BRANCH WAY ROCKVILLE MD 20855 SPEZIALPRAXIS BLUTGERINNUNGSSTORUNGEN FRANKFURT GERMANY UNIV ERLANGEN NURNBERG,KLIN KINDER & JUGENDLICHE D-8520 ERLANGEN GERMANY
Titolo Testata:
Haemophilia
fascicolo: 4, volume: 4, anno: 1998,
pagine: 546 - 551
SICI:
1351-8216(1998)4:4<546:TNOTIT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOPHILIA-A; ANTIBODIES; INHIBITORS; GENE;
Keywords:
FACTOR VIII; HEMOPHILIA A; ANTIBODY; IMMUNE RESPONSE; INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
D. Scandella et al., "THE NATURAL-HISTORY OF THE IMMUNE-RESPONSE TO EXOGENOUS FACTOR-VIII IN SEVERE HEMOPHILIA-A", Haemophilia, 4(4), 1998, pp. 546-551

Abstract

The development of inhibitory antibodies to factor VIII (fVIII) in severe haemophilia A patients is a serious therapeutic complication. Using a highly sensitive immunoprecipitation (IP) assay which measures all anti-fVIII antibodies, we have tested severe haemophilic plasmas from two clinical studies. Inhibitor titres in the range of 0.4 to 1 Bethesda units/ml (BU/ml) could not be verified by IP as being due to an immune response to Nm in 35% of plasmas tested. Low fVIII recoveries were likewise correlated with the presence of antibodies in 29% of plasmas tested, However, 16% of plasmas without inhibitor titres had immuneresponses as measured by IF. The rapidity of antibody appearance did not allow their effective detection by LP before development of inhibitor titres. These results suggest that the LP assay can provide a valuable confirmation of anti-fVIII antibody production when the Bethesda assay is low or negative and where clinical observations suggest theirpresence, but they cannot be used reliably to detect early immune responses.

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Documento generato il 21/09/20 alle ore 06:29:29