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Titolo:
MUSCLE RIGIDITY INDUCED BY FLUPHENAZINE IN RATS IS ANTAGONIZED BY L-DOPA, AN ANTIPARKINSONIAN DRUG
Autore:
OSSOWSKA K; KONIECZNY J; LORENCKOCI E; SCHULZE G; COPER H; WOLFARTH S;
Indirizzi:
POLISH ACAD SCI,INST PHARMACOL,DEPT NEUROPSYCHOPHARMACOL,12 SMETNA STPL-31343 KRAKOW POLAND FREE UNIV BERLIN,DEPT CLIN NEUROBIOL D-1000 BERLIN GERMANY
Titolo Testata:
Journal of Physiology and Pharmacology
fascicolo: 2, volume: 49, anno: 1998,
pagine: 311 - 317
SICI:
0867-5910(1998)49:2<311:MRIBFI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; HALOPERIDOL; RECEPTORS; CATALEPSY; MODEL; TONE;
Keywords:
PARKINSONISM; MUSCLE RIGIDITY; FLUPHENAZINE; L-DOPA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
K. Ossowska et al., "MUSCLE RIGIDITY INDUCED BY FLUPHENAZINE IN RATS IS ANTAGONIZED BY L-DOPA, AN ANTIPARKINSONIAN DRUG", Journal of Physiology and Pharmacology, 49(2), 1998, pp. 311-317

Abstract

The aim of the present study was to find out whether the clasic neuroleptic fluphenazine is a good model compound for inducing parkinsonian-like muscle rigidity in rats. The muscle tone was measured as resistance developed by the rat's hind foot to passive flexion and extension. Fluphenazine in doses of 0.4-3.0 mg/kg ip induced a dose-dependent increase in the hind foot resistance to passive movements. The muscle rigidity induced by fluphenazine (1.5 mg/kg ip) was counteracted in a dose-dependent manner by the main antiparkinsonian drug L-DOPA (25-75 mg/kg ip). The present results suggest that the fluphenazine-induced muscle rigidity may be a useful model of parkinsonian rigidity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:17:30