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Titolo:
THROMBOLYTIC AND ANTIPLATELET ACTION OF XANTHINOL NICOTINATE (SADAMIN), POSSIBLE MECHANISMS
Autore:
BIERON K; SWIES J; KOSTKATRABKA E; GRYGLEWSKI RJ;
Indirizzi:
JAGIELLONIAN UNIV,COLL MED,CHAIR PHARMACOL,UL GRZEGORZECKA 16 PL-31351 KRAKOW POLAND
Titolo Testata:
Journal of Physiology and Pharmacology
fascicolo: 2, volume: 49, anno: 1998,
pagine: 241 - 249
SICI:
0867-5910(1998)49:2<241:TAAAOX>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-PYRIDYLCARBINOL RONICOL; AORTIC ENDOTHELIAL-CELLS; ARTERIOSCLEROSIS OBLITERANS; RELAXING FACTOR; NITRIC-OXIDE; PROSTACYCLIN; RELEASE; ACID;
Keywords:
XANTHINOL NICOTINATE; PROSTACYCLIN; NITRIC OXIDE; THROMBOLYSIS; HYPOTENSIVE ACTION; ANTIPLATELET ACTIVITY; CAMP; CGMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
K. Bieron et al., "THROMBOLYTIC AND ANTIPLATELET ACTION OF XANTHINOL NICOTINATE (SADAMIN), POSSIBLE MECHANISMS", Journal of Physiology and Pharmacology, 49(2), 1998, pp. 241-249

Abstract

Here we report on thrombolytic and hypotensive actions of Xanthinol nicotinate (Sadamin) in rats and on its anti-platelet and fibrinolytic effects in patients with peripheral arterial obliterative disease (PAOD). Special consideration was given to a proposal of new mechanisms ofanti-platelet and thrombolytic actions of Sadamin, We conclude that the mechanism of anti-platelet and thrombolytic activity of Sadamin partly consists of a simultaneous release of endogenous prostacyclin and nitric oxide by the nicotinate component of Sadamin, whereas the theophylline component is responsible for enhancement of physiological actions of these endothelial mediators at the level of cyclic nucleotides which are their second messengers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:52:46