Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INHIBITION OF RAT NA+ K+-ATPASE ISOFORMS BY ENDOGENOUS DIGITALIS EXTRACTS FROM NEONATAL HUMAN PLASMA/
Autore:
CRAMBERT G; BALZAN S; PACI A; DECOLLOGNE S; MONTALI U; GHIONE S; LELIEVRE LG;
Indirizzi:
UNIV PARIS 07,LAB PHARMACOL TRANSPORTS ION MEMBRANAIRES,HALL BIOTECHNOL,2 PL JUSSIEU F-75251 PARIS 05 FRANCE UNIV PARIS 07,LAB PHARMACOL TRANSPORTS ION MEMBRANAIRES F-75251 PARIS05 FRANCE CNR,INST CLIN PHYSIOL I-56126 PISA ITALY UNIV PISA,INST BIOL CHEM PISA ITALY
Titolo Testata:
Clinical and experimental hypertension
fascicolo: 5-6, volume: 20, anno: 1998,
pagine: 669 - 674
SICI:
1064-1963(1998)20:5-6<669:IORNKI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORD BLOOD; BOVINE HYPOTHALAMUS; OUABAIN; PURIFICATION; AFFINITY; MECHANISM; BRAIN;
Keywords:
RAT NA+/K+-ATPASE ISOFORMS; DIGITALIS-LIKE FACTOR; HUMAN PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
G. Crambert et al., "INHIBITION OF RAT NA+ K+-ATPASE ISOFORMS BY ENDOGENOUS DIGITALIS EXTRACTS FROM NEONATAL HUMAN PLASMA/", Clinical and experimental hypertension, 20(5-6), 1998, pp. 669-674

Abstract

An unique endogeneous digitalis-like factor (EDLF) has been previously purified from human newborn cord plasma and its differential effectstested on the three well defined functional isoforms (alpha(1), alpha(2) and alpha(3)) of the alpha subunits of Na+/K+-ATPase in rat. EDLF specifically inhibits the enzymatic activity. It differs from ouabain by three criteria: a preincubation with the membranes is required for full activity, no effect on the rat cerebral alpha(3) isoform and a steep dose-response curve with the same apparent potency for rat a;! andal isoforms of high (10(-7) M) and low affinity (3 x 10(-5) M) for ouabain. These results indicate that the Na+/K+-ATPase inhibitor involved in the regulation of sodium and body fluid volume and present in neonate and adult human plasmas is distinct from ouabain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:52:23