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Titolo:
CORRELATES OF ANTITHROMBIN, PROTEIN-C, PROTEIN-S, AND TFPI IN A HEALTHY ELDERLY COHORT
Autore:
SAKKINEN PA; CUSHMAN M; PSATY BM; KULLER LH; BAJAJ SP; SABHARWAL AK; BOINEAU R; MACY E; TRACY RP;
Indirizzi:
UNIV VERMONT,DEPT PATHOL & BIOCHEM,AQUATEC BLDG,T205,55A S PK DR COLCHESTER VT 05446 UNIV VERMONT,DEPT PATHOL & BIOCHEM COLCHESTER VT 05446 UNIV VERMONT,DEPT MED COLCHESTER VT 05446 UNIV VERMONT,DEPT PATHOL COLCHESTER VT 05446 UNIV WASHINGTON,DEPT MED SEATTLE WA 98195 UNIV WASHINGTON,DEPT EPIDEMIOL & HLTH SERV SEATTLE WA 98195 UNIV PITTSBURGH,DEPT EPIDEMIOL PITTSBURGH PA 15261 ST LOUIS UNIV,DEPT MED ST LOUIS MO 63103 ST LOUIS UNIV,DEPT BIOCHEM ST LOUIS MO 63103 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,NIH BETHESDA MD 20892 UNIV VERMONT,DEPT PATHOL BURLINGTON VT 05405
Titolo Testata:
Thrombosis and haemostasis
fascicolo: 1, volume: 80, anno: 1998,
pagine: 134 - 139
SICI:
0340-6245(1998)80:1<134:COAPPA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED IMMUNOSORBENT-ASSAY; CARDIOVASCULAR HEALTH; HUMAN-PLASMA; RISK-FACTORS; T-PA; INHIBITOR; DISEASE; ATHEROSCLEROSIS; COAGULATION; DEFICIENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Sakkinen et al., "CORRELATES OF ANTITHROMBIN, PROTEIN-C, PROTEIN-S, AND TFPI IN A HEALTHY ELDERLY COHORT", Thrombosis and haemostasis, 80(1), 1998, pp. 134-139

Abstract

The majority of fatal acute myocardial infarctions occur in the elderly, Since these events are predominantly thrombotic, we studied the cross-sectional associations of the anticoagulant proteins Antithrombin. Protein C, Protein S, and Tissue Factor Pathway Inhibitor (TFPI) in asubgroup (n = 400) of the Cardiovascular Health Study (a study of healthy men and women greater than or equal to 65 years) free of clinicalcardiovascular disease (CVD). We did not observe any strong ape-associated trends, although Protein C was lower in older women (p less thanor equal to 0.001). and TFPI was higher in older men (p less than or equal to 0.01). The inhibitors were highly intercorrelated, and were associated with increased levels of inflammation-sensitive proteins (e.g., fibrinogen, plasminogen), lipids (especially total and LDL-cholesterol), and coagulation factors, such as Factors VIIc, IXc, and Xc. None was associated with the procoagulant markers Prothrombin Fragment FI-2 or Fibrinopeptide A. Only TFPI was associated with subclinical atherosclerosis: ankle-arm index and internal carotid artery stenosis, p trend less than or equal to 0.01; and carotid wall thickness, p trend less than or equal to 0.05. In multivariate analysis the independent predictors of TFPI were levels of fibrinogen: the fibrinolytic marker plasmin-antiplasmin complex: LDL-cholesterol: and carotid wall thickness(R-2 for the model = 0.35). In summary, the inhibitors did not appearto increase with age. and were predominantly associated with inflammation markers and lipids. Since markers of thrombin production do increase with age, we hypothesize that an age-related hemostatic imbalance may ensue, with associated increased thrombotic risk. Only TFPI was associated with subclinical CVD, suggesting that it may more closely reflect endothelial damage. (250)

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Documento generato il 30/11/20 alle ore 12:33:41