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Titolo:
MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY FOR THERAPEUTIC DRUG-MONITORING OF CARBAMAZEPINE AND ITS MAIN METABOLITES
Autore:
HARTTER S; JENSEN B; HIEMKE C; LEAL M; WEIGMANN H; UNGER K;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-6500 MAINZ GERMANY BOEHRINGER INGELHEIM KG,DEPT ANALYT SCI D-6507 INGELHEIM GERMANY UNIV MAINZ,INST INORGAN & ANALYT CHEM D-6500 MAINZ GERMANY
Titolo Testata:
Journal of chromatography B. Biomedical sciences and applications
fascicolo: 1-2, volume: 712, anno: 1998,
pagine: 253 - 258
SICI:
0378-4347(1998)712:1-2<253:MECCFT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIEPILEPTIC DRUGS; AFFECTIVE-DISORDERS; EPILEPTIC PATIENTS; BODY-FLUIDS; SERUM; ELECTROPHORESIS; PERFORMANCE; EPOXIDE;
Keywords:
CARBAMAZEPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S. Hartter et al., "MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY FOR THERAPEUTIC DRUG-MONITORING OF CARBAMAZEPINE AND ITS MAIN METABOLITES", Journal of chromatography B. Biomedical sciences and applications, 712(1-2), 1998, pp. 253-258

Abstract

In carbamazepine (CBZ) therapy the concomitant monitoring of concentrations of CBZ and its metabolites is strictly recommended, primarily to avoid toxic side effects. Currently, clinical routine monitoring of CBZ is accomplished by high-performance liquid chromatography or immunological methods. In this study a micellar electrokinetic capillary chromatographic (MECC) method was developed for routine drug monitoring of CBZ and its main metabolites, carbamazepine 10,11-diol and carbamazepine 10,11-epoxide, in human serum or plasma samples. The MECC methodenabled baseline separation of all analytes within 2.5 min. The assayrevealed sufficient precision and sensitivity and the results of either an automated HPLC or the MECC chromatography assay were in good agreement (r=greater than or equal to 0.97). The maximum deviation for CBZ was 0.26 mu M. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:10:21