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Titolo:
DETERMINATION OF CLOZAPINE AND ITS METABOLITE, N-DESMETHYLCLOZAPINE, IN SERUM MICROSAMPLES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND ITS APPLICATION TO PHARMACOKINETICS IN RATS
Autore:
MA F; LAU CE;
Indirizzi:
RUTGERS STATE UNIV,DEPT PSYCHOL,152 FRELINGHUYSEN RD PISCATAWAY NJ 08854 RUTGERS STATE UNIV,DEPT PSYCHOL PISCATAWAY NJ 08854
Titolo Testata:
Journal of chromatography B. Biomedical sciences and applications
fascicolo: 1-2, volume: 712, anno: 1998,
pagine: 193 - 198
SICI:
0378-4347(1998)712:1-2<193:DOCAIM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLID-PHASE EXTRACTION; ULTRAVIOLET DETECTION; MAJOR METABOLITES; HUMAN PLASMA; NORCLOZAPINE; COCAINE;
Keywords:
CLOZAPINE; N-DESMETHYLCLOZAPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
F. Ma e C.E. Lau, "DETERMINATION OF CLOZAPINE AND ITS METABOLITE, N-DESMETHYLCLOZAPINE, IN SERUM MICROSAMPLES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND ITS APPLICATION TO PHARMACOKINETICS IN RATS", Journal of chromatography B. Biomedical sciences and applications, 712(1-2), 1998, pp. 193-198

Abstract

A single solvent extraction step high-performance liquid chromatographic method is described for quantitating clozapine and its metabolite,N-desmethylclozapine, in rat serum microsamples (50 mu l) The separation used a 2.1-mm I.D. reversed-phase Symmetry C-18 column with an isocratic mobile phase consisting of methanol-acetonitrile-28.6 mM sodiumacetate buffer, pH 2.6 (10:20:70, v/v/v). The detection limit was 2.5ng/ml for all the compounds using an ultraviolet detector operated at230 nm. The method was used to study the pharmacokinetics of clozapine after an intravenous bolus dose (2.5 mg/kg). (C) 1998 Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:29:26